The team was able to successfully prescribe cytokine inhibitors to efficiently suppress the patients’ constitutive inflammation. The authors conclude their paper by suggesting that targeted cytokine therapies may be useful in diseases related to defects in the ubiquitin pathway.
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Lara C. Pullen, PhD, is a medical writer based in the Chicago area.
- Zhou Q, Yu X, Demirkaya E, et al. Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease. Proc Natl Acad Sci USA. 2016 Sep 6;113(36):10127–10132. doi: 10.1073/pnas.1612594113. Epub 2016 Aug 24.