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Pathophysiology of Gouty Tophi

Lara C. Pullen, PhD  |  March 19, 2018

In a recent study, researchers examined synovial fluid and non-inflamed tophi from the acutely inflamed joints of patients with gout, finding that monosodium urate (MSU) crystals trigger a distinct physiological NETosis pathway that coats MSU crystals in DNA that persists in tissues as gouty tophi…

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The FDA Approved Several New Rheumatology Drugs in 2017

Larry Beresford  |  March 18, 2018

SAN DIEGO—In a session at the 2017 ACR/ARHP Annual Meeting, Kam Nola, PharmD, MS, professor in the College of Pharmacy and vice chair in the Department of Pharmacy Practice at Lipscomb University in Nashville, Tenn., updated participants on new medications and new indications for rheumatology treatments and safety labeling changes approved by the U.S. Food…

Professor Shares Findings from 45 Years of Lupus Research

Susan Bernstein  |  March 18, 2018

SAN DIEGO—What are the predisposing genes that suggest who will develop active systemic lupus erythematosus and who will stay healthy? Decades of research data help rheumatologists clarify this picture, says Argyrios N. Theofilopoulos, MD, professor of immunology and microbiology at Scripps Research Institute in La Jolla, Calif. At his Nov. 5 lecture at the 2017…

Translating Genetic Discoveries into Rheumatic Therapies

Susan Bernstein  |  March 18, 2018

SAN DIEGO—Will rheumatologists soon be able to use data from genetics and genome-wide association studies to more accurately predict disease and develop new therapies for rheumatic diseases? At a Nov. 5 session at the 2017 ACR/ARHP Annual Meeting, experts shared their views on how to glean this useful knowledge from genomics studies. The cost to develop…

SLE Remission: The Treat-to-Target Approach

Susan Bernstein  |  March 17, 2018

SAN DIEGO—Treatment strategies for systemic lupus erythematosus (SLE) have changed a great deal over the years, but progress has been slow and inadequate. According to a 2011 survey, many patients with lupus still report that they have a low quality of life due to their health problems.1 Rheumatologists face the challenge to develop more successful…

Updates on Managing Lupus Complications

Susan Bernstein  |  March 17, 2018

SAN DIEGO—To manage patients with systemic lupus erythematous (SLE), rheuma­tologists must be aware of potentially serious complications affecting many organ systems. On Nov. 7 at the 2017 ACR/ARHP Annual Meeting, two experts offered insights on cardiovascular and hematological complications of lupus. Myocardial Disease in Lupus Lupus patients are at increased risk for heart-related complications, especially…

2 Fellowship Directors Debate ACGME Milestones Eval System

Larry Beresford  |  March 17, 2018

SAN DIEGO—The Next Accreditation System, the newest process for evaluating medical residency and fellowship programs and their participants, including future rheumatologists, was implemented in 2014 by the Accreditation Council for Graduate Medical Education (ACGME). The system introduced specialty-specific milestones designed to reflect significant points in professional development. Milestones are defined by ACGME as a rubric…

DMARDs & Biologics Info for Rheumatology Nurses

Larry Beresford  |  March 17, 2018

SAN DIEGO—In a presentation on what rheumatology nurses should know in their daily practice about disease-modifying anti-rheumatic drugs (DMARDs) at the 2017 ACR/ARHP Annual Meeting Nov. 3–8, Jessica Farrell, PharmD, highlighted the importance of educating and counseling patients about the range of treatments and applications for rheumatologic conditions. Dr. Farrell, a clinical pharmacist at the…

Tips for Diagnosing & Treating Shoulder & Low Back Pain

Thomas R. Collins  |  March 17, 2018

SAN DIEGO—At two sports medicine talks at the 2017 ACR/ARHP 2017 Annual Meeting last November, two rheumatologists discussed shoulder impingement and low back pain. First, Andrew Concoff, MD, a rheumatology and sports medicine specialist at St. Jude Medical Center in Fullerton, Calif., gave these five shoulder impingement tips: Physical exams may not be very useful…

Transcriptional Programming Research, & a Twist on CAR-T Cell Therapy

Thomas R. Collins  |  March 17, 2018

SAN DIEGO—At the 2017 ACR/ARHP Annual Meeting this past November, an expert said researchers are making progress in identifying drugs that can correct problems with transcriptional programming, which, if perfected, could go a long way toward harnessing more fully the power of genetics knowledge and directing it toward patient care. The session also delved into…

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