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An official publication of the ACR and the ARP serving rheumatologists and rheumatology professionals

Methotrexate with Step-Down Glucocorticoid Remission Induction Works in Early RA

Reuters Staff  |  

NEW YORK (Reuters Health)—Methotrexate with step-down glucocorticoid remission induction (COBRA Slim) is an effective, safe and feasible initial treatment strategy for patients with early rheumatoid arthritis (RA), researchers from Belgium report. Patients with early RA should be treated rapidly, intensively and to target, according to current guidelines, they note in a paper online July 18…

Ultrasound May Be Useful for Grading Rotator Cuff Tendinopathy

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Researchers have developed procedures and assessed their efficacy for the use of ultrasound images to measure the inter-rater reliability of the measurement of structural changes in the tendon of patients with supraspinatus tendinopathy. The standardized procedures proved useful in evaluating patients…

Secukinumab Inhibits Structural Joint Damage in Active PsA

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Psoriatic arthritis (PsA), a chronic inflammatory arthritis characterized by structural damage to the joints, has been associated with reduced health-related quality of life, disability and reduced life expectancy. The joint changes in PsA are characterized radiographically by a combination of erosive and proliferative bone changes, including erosive joint destruction, fluffy periostitis and pencil-in-cup deformities. Radiographic…

Healthy Clones: Dolly the Sheep’s Heirs Reach Ripe Old Age

Ben Hirschler  |  

LONDON (Reuters)—The heirs of Dolly the sheep are enjoying a healthy old age, proving cloned animals can live normal lives and offering reassurance to scientists hoping to use cloned cells in medicine. Dolly, cloning’s poster child, was born in Scotland in 1996. She died prematurely in 2003, at age 6, after developing osteoarthritis and a…

EMA Flags Faulty Generic Drug Data, Backs Sales Halt

Reuters Staff  |  

(Reuters)—The European Medicines Agency (EMA) recommended suspending sales of some generic drugs after a review found that data collected by a contract research company in India for their approval was unreliable. The EMA’s list included drugs made by some of the top generic drugmakers, including Teva Pharmaceutical Industries Ltd., Mylan NV and Novartis AG’s Sandoz….

MicroRNA Mediates Gene Regulation That Underlies JIA Pathology

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Through the use of large-scale transcriptome analysis, researchers have gained insight into the role of innate immunity in juvenile idiopathic arthritis (JIA) pathology. Specifically, transcriptomes of neutrophils in chronic inflammatory states demonstrate extensive network rewiring caused by microRNA, suggesting a role for alternative splicing in JIA pathogenesis…

U.S. Regulators Sue to Block Anthem-Cigna & Aetna-Humana Mergers

Caroline Humer & Carl O'Donnell  |  

NEW YORK (Reuters)—U.S. antitrust officials on Thursday moved to block an unprecedented consolidation of the national health insurance market, filing suit against Anthem Inc.’s proposed purchase of Cigna Corp. and Aetna Inc.’s planned acquisition of Humana Inc. The U.S. Department of Justice (DOJ) says the two mergers would reduce competition, raise prices for consumers and…