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Infliximab Biosimilar Cross Reacts to Infliximab Antibodies; Plus Treat-to-Target Strategy Promising for Treating RA with bDMARDs

Michele B. Kaufman, PharmD, BCGP  |  July 6, 2016

In a recent study, 100% of patients with rheumatoid arthritis (RA) on infliximab experienced a cross-reaction when switched to its biosimilar (CT-P13, infliximab-dyyb). Plus in a recent study, a treat-to-target strategy proved effective for treating RA with biological disease-modifying anti-rheumatic drugs…

GI Side Effects Leading Reason for Bisphosphonate Nonadherence

Reuters Staff  |  July 6, 2016

NEW YORK (Reuters Health)—Gastrointestinal side effects are the most common reason osteoporotic women cite for nonadherence to oral bisphosphonate therapy, according to a new survey. “Our findings highlight the importance of low tolerability to nonadherence with osteoporosis therapy and underlines patients’ poor awareness and suboptimal physicians’ involvement in conveying the importance of this therapy,” Dr….

Biosimilars: Unanswered Questions

Susan Bernstein  |  July 5, 2016

Debate continues about how biosimilars that are emerging to treat rheumatic diseases will be named and monitored, said panelists at a recent meeting in Washington, D.C.—Biosimilars in the United States: Next Steps. Angus Worthing, MD, FACR, FACP, a member of the ACR’s Government Affairs Committee, shared rheumatologists’ concerns as these new therapies come to market….

Prepare Now to Survive MACRA

Kelly Tyrrell  |  July 5, 2016

The year 2015 brought an end to the much-maligned Sustainable Growth Rate (SGR), sometimes known as the “doc fix.” The SGR established limits on Medicare reimbursement for physicians, and each year, physicians and those lobbying on their behalf were forced to stave off drastic cuts to their payments. “The SGR was Congress’s attempt to control…

RA Choice: A Tool to Improve Patient Literacy

Arthritis Care & Research  |  July 5, 2016

Doctor-patient communication is critical for successfully treating rheumatoid arthritis. But a majority of RA patients report suboptimal shared decision making, sometimes due to language barriers, lack of time, limited health literacy and other factors. A recent pilot study sought to improve patient understanding and communication by employing an adapted medication guide and decision aid during clinical visits. Use of the tool, RA Choice, resulted in an increase in patient knowledge, and a majority of clinicians found it helpful…

Spanish Drugmaker Fears Disruption if EMA Moves from Britain

Emma Pinedo  |  July 4, 2016

MADRID (Reuters)—The likely relocation of the European Medicines Agency (EMA) from London threatens to disrupt the approval of new drugs and is a medium and long-term worry for top Spanish drugmaker Almirall, its chief executive says on Monday. The EMA, Europe’s equivalent the U.S. Food and Drug Administration, approves medicines for all European Union countries…

Statin Use Tied to Lower Risk of Inflammatory Bowel Disease

Megan Brooks  |  July 4, 2016

NEW YORK (Reuters Health)—Statin use is associated with a lower risk of developing inflammatory bowel disease (IBD), especially Crohn’s disease in older patients, new research suggests. “Prior studies have suggested that statins can decrease inflammation and may improve IBD in patients who already have the disease. To our knowledge, this is the first study to show…

Periodontal Infection May Determine Best Treatment for Patients with RA

Lara C. Pullen, PhD  |  July 4, 2016

Past research has indicated that a periodontal pathogen that produces the peptidularginine deiminase (PPAD) enzyme may affect levels of anti-cyclic citrullinated peptide antibody. A new study suggests serum anti-PPAD IgG titers might be a useful biomarker for designing a personalized treatment strategy for RA…

Family History Biggest Predictor of Heart Attacks in People with Psoriasis

Lisa Rapaport  |  July 2, 2016

(Reuters Health)—People with psoriasis, a chronic inflammatory disease, are more likely to have heart attacks and strokes when they have a family history of cardiovascular problems, a Danish study suggests. Psoriasis wasn’t associated with higher risk of heart attacks or strokes when people with the skin condition didn’t have a family history of cardiovascular disease,…

Patients with Gout May Not Understand Serum Urate Goals & Treatments

Richard Quinn  |  July 1, 2016

New research has found that a minority of gout patients understands the importance of their serum urate goals. Ted Mikuls, MD, MSPH, says the study shines a light on a gap in patient education providers can address…

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