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Research Provides Insight into Impact of Microbiome on Health, Rheumatic Disease

Neha Ohri, MD, & Kristine A. Kuhn, MD, PhD  |  Issue: April 2016  |  

Neha Ohri, MD, is a third-year rheumatology fellow at the University of Colorado School of Medicine, Aurora, Colo.

Kristine Kuhn, MD, PhD, is an assistant professor of medicine in the Division of Rheumatology at the University of Colorado School of Medicine. Her research focuses upon the interactions of the microbiome and mucosa on the development of systemic autoimmunity.

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References

  1. Gest H. The discovery of microorganisms by Robert Hooke and Antoni Van Leeuwenhoek, fellows of the Royal Society. Notes Rec R Soc Lond. 2004;58(2):187–201.
  2. Silman AJ, MacGregor AJ, Thomson W, et al. Twin concordance rates for rheumatoid arthritis: Results from a nationwide study. Br J Rheumatol. 1993;32(10):903–907.
  3. Cecil RL, Nicholls EE, Stainsby WJ. The etiology of rheumatoid arthritis. Am J Med Sci. 1931;181(1):12–24.
  4. Ogrendik M. Antibiotics for the treatment of rheumatoid arthritis. Int J Gen Med. 2013 Dec 27;7:43–47. doi:10.2147/IJGM.S56957.
  5. Zhang X, Zhang D, Jia H, et al. The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment. Nat Med. 2015 Aug;21(8):895–905. doi:10.1038/nm.3914.
  6. Mikuls TR, Thiele GM, Deane KD, et al. Porphyromonas gingivalis and disease-related autoantibodies in individuals at increased risk of rheumatoid arthritis. Arthritis Rheum. 2012 Nov;64(11):3522–3530. doi:10.1002/art.34595.
  7. Bello-Gualtero JM, Lafaurie GI, Hoyos LX, et al. Periodontal disease in individuals with a genetic risk of developing arthritis or with early rheumatoid arthritis: A cross-sectional study. J Periodontol. 2015 Nov 26;1–18. doi:10.1902/jop.2015.150455.
  8. Terao C, Asai K, Hashimoto M, et al. Significant association of periodontal disease with anti-citrullinated peptide antibody in a Japanese healthy population—The Nagahama study. J Autoimmun. 2015 May;59:85–90. doi:10.1016/j.jaut.2015.03.002.
  9. Willis VC, Demoruelle MK, Derber LA, et al. Sputum autoantibodies in patients with established rheumatoid arthritis and subjects at risk of future clinically apparent disease. Arthritis Rheum. 2013 Oct;65(10):2545–2554. doi:10.1002/art.38066.
  10. Scher JU, Sczesnak A, Longman RS, et al. Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis. Elife. 2013 Nov 5;2:e01202. doi:10.7554/eLife.01202.
  11. Walters WA, Xu Z, Knight R. Meta-analyses of human gut microbes associated with obesity and IBD. FEBS Lett. 2014 Nov 17;588(22):4223–4233. doi:10.1016/j.febslet.2014.09.039.
  12. Arvikar SL, Fisher MC. Inflammatory bowel disease associated arthropathy. Curr Rev Musculoskelet Med. 2011 Sep;4(3):123–131. doi:10.1007/s12178-011-9085-8.
  13. Kuhn KA, Pedraza I, Demoruelle MK. Mucosal immune responses to microbiota in the development of autoimmune disease. Rheum Dis Clin North Am. 2014 Nov;40(4):711–725. doi:10.1016/j.rdc.2014.07.013.
  14. Ge S, He Q, Granfors K. HLA-B27 modulates intracellular growth of Salmonella pathogenicity island 2 mutants and production of cytokines in infected monocytic U937 cells. PLoS One. 2012;7(3):e34093. doi:10.1371/journal.pone.0034093.
  15. Laitio P, Virtala M, Salmi M, et al. HLA-B27 modulates intracellular survival of Salmonella enteritidis in human monocytic cells. Eur J Immunol. 1997 Jun;27(6):1331–1338.
  16. Penttinen MA, Heiskanen KM, Mohapatra R, et al. Enhanced intracellular replication of Salmonella enteritidis in HLA-B27-expressing human monocytic cells: Dependency on glutamic acid at position 45 in the B pocket of HLA-B27. Arthritis Rheum. 2004 Jul;50(7):2255–2263. doi:10.1002/art.20336.
  17. Jacques P, Elewaut D. Joint expedition: Linking gut inflammation to arthritis. Mucosal Immunol. 2008 Sep;1(5):364–371. doi:10.1038/mi.2008.24.
  18. Alekseyenko AV, Perez-Perez GI, De Souza A, et al. Community differentiation of the cutaneous microbiota in psoriasis. Microbiome. 2013 Dec 23;1(1):31. doi:10.1186/2049-2618-1-31.
  19. Castelino M, Eyre S, Tutino M, et al. Bacterial skin microbiome in psoriatic arthritis—Pilot data from psoriatic plaques on dry skin sites from patients with psoriasis (PsC) and psoriatic arthritis (PsA). 2015 ACR/ARHP Annual Meeting. Abstract Number: 2806. 2015 Sep 29.
  20. Scher JU, Ubeda C, Artacho A, et al. Decreased bacterial diversity characterizes the altered gut microbiota in patients with psoriatic arthritis, resembling dysbiosis in inflammatory bowel disease. Arthritis Rheumatol. 2015 Jan;67(1):128–139. doi:10.1002/art.38892.
  21. Duncan SH, Barcenilla A, Stewart CS, et al. Acetate utilization and butyryl coenzyme A (CoA): Acetate-CoA transferase in butyrate-producing bacteria from the human large intestine. Appl Environ Microbiol. 2002 Oct;68(10):5186–5190. doi:10.1128/AEM.68.10.51865190.2002.
  22. Vinolo MAR, Rodrigues HG, Nachbar RT, Curi R. Regulation of inflammation by short chain fatty acids. Nutrients. 2011 Oct;3(10):858–876. doi:10.3390/nu3100858.
  23. Ebringer R, Cawdell D, Ebringer A. Klebsiella pneumoniae and acute anterior uveitis in ankylosing spondylitis. Br Med J. 1979 Feb 10;1(6160):383.
  24. Ebringer RW, Cawdell DR, Cowling P, Ebringer A. Sequential studies in ankylosing spondylitis. Association of Klebsiella pneumoniae with active disease. Ann Rheum Dis. 1978 Apr;37(2):146–151.
  25. Stebbings S. Comparison of the faecal microflora of patients with ankylosing spondylitis and controls using molecular methods of analysis. Rheumatology (Oxford). 2002 Dec;41(12):1395–1401.
  26. Costello M-E, Ciccia F, Willner D, et al. Intestinal dysbiosis in ankylosing spondylitis. Arthritis Rheumatol. 2014 Nov 21. doi:10.1002/art.38967.
  27. Stoll ML, Kumar R, Morrow CD, et al. Altered microbiota associated with abnormal humoral immune responses to commensal organisms in enthesitis-related arthritis. Arthritis Res Ther. 2014 Nov 30;16(6):486. doi:10.1186/s13075-014-0486-0.
  28. Hevia A, Milani C, López P, et al. Intestinal dysbiosis associated with systemic lupus erythematosus. MBio. 2014 Sep 30;5(5):e01548–01514. doi:10.1128/mBio.01548-14.
  29. Sandhya P, Sharma D, Vellarikkal SK, et al. AB0188 systematic analysis of the oral microbiome in primary Sjögren’s syndrome suggest enrichment of distinct microbes. Ann Rheum Dis. 2015 May;74(Suppl 2):953.3–954.
  30. Consolandi C, Turroni S, Emmi G, et al. Behçet’s syndrome patients exhibit specific microbiome signature. Autoimmun Rev. 2015 Apr;14(4):269–276.
  31. Brandt LJ, Aroniadis OC, Mellow M, et al. Long-term follow-up of colonoscopic fecal microbiota transplant for recurrent clostridium difficile infection. Am J Gastroenterol. 2012 Jul;107(7):1079–1087. doi:10.1038/ajg.2012.60.
  32. Rossen NG, MacDonald JK, de Vries EM, et al. Fecal microbiota transplantation as novel therapy in gastroenterology: A systematic review. World J Gastroenterol. 2015 May 7;21(17):5359–5371. doi:10.3748/wjg.v21.i17.5359.
  33. American Gut. What’s in your gut?.
  34. Consortium TIH (iHMP) RN. The Integrative Human Microbiome Project: Dynamic analysis of microbiome-host omics profiles during periods of human health and disease. Cell Host Microbe. 2014 Sep 10;16(3):276–289. doi:10.1016/j.chom.2014.08.014.
  35. Alfred R. Sept. 17, 1683: Van Leeuwenhoek gives us reason to brush and floss. Wired. 2008 Sep 17.

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