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Research Update: Using Vagus Nerve Stimulation for Rheumatic Disease

Mary Beth Nierengarten  |  Issue: April 2023  |  April 8, 2023

Dr. Kameneva

Further guidance on individualizing VNS treatment may come from a more detailed understanding of changes in brain activity caused by stimulation of the vagus nerve. A study by investigators from Australia reported on the simultaneous use of magnetoencephalography with tVNS to gain insight into regions of the brain most influenced by stimulating the vagus nerve.4 “We have shown that varying the stimulation frequency can lead to a difference in brain response, with the brain also responding in different anatomical regions depending on the frequency,” says senior author of the study, Tatiana Kameneva, PhD, senior lecturer, School of Science, Computing and Engineering Technologies, Swinburne University of Technology, Hawthorn, Australia.

“This may lead to the development of customized therapeutic approaches for the targeted treatment of different conditions, possibly to rheumatologic diseases.”

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Mary Beth Nierengarten is a freelance medical journalist based in Minneapolis.

References

  1. Genovese MC, Gaylis NB, Sikes D, et al. Safety and efficacy of neurostimulation with a miniaturized vagus nerve stimulation device in patients with multidrug-refractory rheumatoid arthritis: A two-stage multicentre, randomized pilot study. Lancet Rheumatol. 2020 Sep;2(9):e527–e538.
  2. Courties A, Deprouw C, Rousseau A, et al. Transcutaneous vagus nerve stimulation in erosive hand osteoarthritis: Protocol for the randomized, double-blind, sham-controlled ESTIVAL trial. BMJ Open. 2022 Mar 22;12(3):e56169.
  3. Caravaca AS, Gallina AL, Tarnawski L, et al. Vagus nerve stimulation promotes resolution of inflammation by a mechanism that involves Alox15 and requires the α7nAChR subunit. Proc Natl Acad Sci U S A. 2022 May 31;119(22):e2023285119.
  4. Keatch C, Lambert E, Woods W, Kameneva T. Measuring brain response to transcutaneous vagus nerve stimulation (tVNS) using simultaneous magnetoencephalography (MEG). J Neural Eng. 2022 Apr 13:19(2):026038.
  5. Koopman FA, Chavan SS, Miljko S, et al. Vagus nerve stimulation inhibits cytokine production and attenuates disease severity in rheumatoid arthritis. Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):8284–8289.
  6. Koopman FA, Musters A, Backer M, et al. SATO240 Vagus nerve stimulation in patients with rheumatoid arthritis: Two-year safety and efficacy [abstract]. Annals of the Rheumatic Dis. 2018;77(suppl 2):981–982.
  7. Koopman FA, Musters A, Backer M, et al. AB1318-HPR Vagus nerve stimulation in patients with rheumatoid arthritis: 48 month safety and efficacy [abstract]. Annals of the Rheumatic Dis. 2020;79(suppl 1): 1948–1949.
  8. Addorisio ME, Imperato GH, de Vos AF, et al. Investigational treatment of rheumatoid arthritis with a vibrotactile device applied to the external ear. Bioelectron Med. 2019 Apr 17;5:4.
  9. Marsal S, Corominas H, De Agustin De Oro JJ, et al. Non-invasive vagus nerve stimulation improves signs and symptoms of rheumatoid arthritis: Results of a pilot study [abstract]. Arthritis Rheumatol. 2020;72 (suppl 10).
  10. Drewes AM, Brock C, Rasmussen SE, et al. Short-term transcutaneous non-invasive vagus nerve stimulation may reduce disease activity and pro-inflammatory cytokines in rheumatoid arthritis: Results of a pilot study. Scan J Rheumatol. 2021 Jan; 50(1):20–27.
  11. Courties A, Berenbaum F, Sellam J. Vagus nerve stimulation in musculoskeletal diseases. Joint Bone Spine. 2021 May; 88(3):105149.
  12. Brock C, Rasmussen SE, Drewes AM, et al. Vagal nerve stimulation-modulation of the anti-inflammatory response and clinical outcome in psoriatic arthritis or anklyosing spondylitis. Mediators Inflamm. 2021 May 27;2021:9933532.
  13. Courties A, Deprouw C, Maheu E, et al. Effect of transcutaneous vagus nerve stimulation in erosive hand osteoarthritis: Results from a pilot trial. J Clin Med. 2022 Feb 18;11(4):1087.

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