Resunab for Systemic Sclerosis Receives FDA Fast-Track Status
Systemic sclerosis (scleroderma) affects mostly women in mid-life and is a rare, serious and chronic autoimmune disorder. There are no treatments approved by the FDA, and the disease confers significant morbidity and mortality.
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Resunab has received FDA fast-track development status for treating systemic sclerosis.1 It entered Phase 2 clinical trials, in a double-blind, randomized, placebo-controlled study, which began in June, to evaluate its safety, tolerability, pharmacokinetics and efficacy in 36 patients aged 18–70 years with active diffuse cutaneous systemic sclerosis.2
Resunab is a novel, synthetic, oral endocannabinoid drug, which mimics the pharmacological effects of cannabinoids. It specifically binds to CB2 receptors on immune cells and fibroblasts. Non-clinical studies have shown that when resunab binds to CB2 it activates the production of specialized pro-resolving lipid mediators (SPMs), which stimulate an endogenous cascade accountable for resolving fibrosis and inflammation. The outcome of this cascade restores chronically activated immune systems back to homeostasis, while halting fibrosis and without causing immunosuppression.
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Debendro Singh says
September 21, 2015 at 5:07 amI am interesting to read about the Scleroderma. My mother has been suffering from the scleroderma since one year. So, I have been searching for
perfect medicine of scleroderma. I feel so excited that Resunab has been approved by FDA.
Raja choudhry says
April 5, 2018 at 9:45 amHey i am raja from india ghaziabad i have also scleroderma i am also trying for resunab
Debendro Singh says
September 21, 2015 at 5:14 amI’m from India. Is Resunab available in India? From where will I get ? Please give me the address. I want to purchase for my mother who has been laying on bed due to
scleroderma disease.
Keri Losavio says
September 21, 2015 at 7:54 pmYou’ll need to contact your doctor for that information or the company that makes it: http://www.corbuspharma.com/contact
Taibing Wei says
April 17, 2017 at 12:54 amI‘m from china，a lovely girl’s father.My heart is broken cause my daughter get Dermatomyositis which will ruin her future. She is only 6 years old, so young and so beautiful.I love her so much. I really want to know how and when can i get the resunab. please help us.