International Carol Nachman Prize
Lars Klareskog, MD, PhD, professor at the Rheumatology Clinic and Rheumatology Research Unit of the Karolinska Institutet and Karolinska Hospital in Stockholm, Sweden, was awarded the International Carol Nachman Prize, the highest international honor for rheumatology, in Wiesbaden, Austria this year. Dr. Klareskog received this award in recognition for his work on the etiology of rheumatoid arthritis (RA). Focusing on immune system activation and regulation,his research looks closely at the influence of genes and environment on the disease.
Explore This IssueDecember 2008
Dr. Klareskog brought together a group of expert geneticists and epidemiologists to explore the interplay of the environment and genetics in RA. “The … major contributions mentioned in motivation for the prize were based on what we did in the eighties, that was studying a particular molecule called a transplantation antigen in its role in immune activation in RA,” he explains. “We pursued this observation by studying how environmental stimuli such as smoking interact with this transplantation antigen in giving rise to reactions that may cause RA. That means we understand how genes and the environment interact in causing the disease.” Of the impact of his research, he says, “I think we have contributed to . . . studying the process that occurs in early stages of the disease even before the onset of symptoms and. . . This may allow us to make intervention both by prevention and therapy.”