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Ro60 Autoantigen Regulates Inflammatory Gene Expression

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The team concluded that Ro60 binds to Alu and primes the RNA-binding innate immune receptors within B cells. This then causes the B cells to make antibodies that target Ro60-Alu RNA, thereby driving disease-causing inflammation.

Lara C. Pullen, PhD, is a medical writer based in the Chicago area.

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References

  1. Hung T, Pratt GA, Sundararaman B, et al. The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression. Science. 2015 Oct 23;350(6259):455–459. doi: 10.1126/science.aac7442. Epub 2015 Sep 17.

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