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Sonographic Diagnosis of Knuckle Pads

Pankaj Bansal, MD, RhMSUS, Eugene Kissin, MD, RhMSUS, & Fawad Aslam, MBBS, RhMSUS, RMSK  |  Issue: October 2022  |  October 10, 2022

FIGURES 4 & 5: Palmar longitudinal and transverse B-mode ultrasound views of the Dupuytren’s contracture. An ill-defined hypoechoic lesion superficial to the flexor tendon proximal to the metacarpophalangeal joint can be seen (dotted line). Key: MC: metacarpal; PP: proximal phalanx; MP: Middle phalanx; FT: flexor tendon. (Click to enlarge.)

Ganglion cysts are usually soft, non-tender cystic to firm swellings and can be present, rarely, on the dorsal aspect of the PIP joints. On musculoskeletal ultrasound, they are anechoic to hypoechoic with increased posterior acoustic enhancement.13 Ganglion cysts are usually seen in proximity to underlying tendons and can originate from the tenosynovium of the tendon. Power Doppler does not usually reveal hypervascularity, and the joint underneath is normal.10

Bouchard nodes are firm to hard, non-tender nodules seen on the dorsal aspect of the PIP joints in osteoarthritis. Ultrasound usually reveals underlying osteophytes and can reveal joint effusion. Erosions can be detected by musculoskeletal ultrasound in erosive osteoarthritis.14

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In Sum

Knuckle pads are benign, subcutaneous, soft-tissue nodules. Musculoskeletal ultrasound can be a useful tool in diagnosing knuckle pads and ruling out other etiologies.


Pankaj Bansal, MD, RhMSUS, serves in the Department of Rheumatology, Mayo Clinic Health System, Eau Claire, Wis.

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Eugene Kissin, MD, RhMSUS, is a clinical professor in the Division of Rheumatology, Boston University School of Medicine.

Fawad Aslam, MBBS, RhMSUS, RMSK, is a rheumatologist at the Mayo Clinic in Scottsdale, Ariz.

References

  1. Nenoff P, Woitek G. Images in clinical medicine. Knuckle pads. N Engl J Med. 2011 Jun 23;364(25):2451.
  2. Mikkelsen OA. Knuckle pads in Dupuytren’s disease. Hand. 1977 Oct;9(3):301–305.
  3. Dickens R, Adams BB, Mutasim DF. Sportsrelated pads. Int J Dermatol. 2002 May;41(5):291–293.
  4. Rayan GM, Ali M, Orozco J. Dorsal pads versus nodules in normal population and Dupuytren’s disease patients. J Hand Surg. 2010 Oct;35(10):1571–1579.
  5. Tamborrini G, Gengenbacher M, Bianchi S. Knuckle pads—A rare finding. J Ultrason. 2012 Dec;12(51):493–498.\
  6. Lopez-Ben R, Dehghanpisheh K, Chatham WW, et al. Ultrasound appearance of knuckle pads. Skeletal Radiol. 2006 Nov;35(11):823–827.
  7. Morris G, Jacobson JA, Kalume Brigido M, et al. Ultrasound features of palmar fibromatosis or Dupuytren contracture. J Ultrasound Med. 2019 Feb;38(2):387–392.
  8. Hmamouchi I, Bahiri R, Srifi N, et al. A comparison of ultrasound and clinical examination in the detection of flexor tenosynovitis in early arthritis. BMC Musculoskelet Disord. 2011 May 8;12:91.
  9. Thiele RG, Schlesinger N. Diagnosis of gout by ultrasound. Rheumatology (Oxford). 2007 Jul;46(7):1116–1121.
  10. Nalbant S, Corominas H, Hsu B, et al. Ultrasonography for assessment of subcutaneous nodules. J Rheumatol. 2003 Jun;30(6):1191–1195.
  11. Ogdie A, Taylor WJ, Neogi T, et al. Performance of ultrasound in the diagnosis of gout in a multicenter study: Comparison with monosodium urate monohydrate crystal analysis as the gold standard. Arthritis Rheumatol. 2017 Feb;69(2):429–438.
  12. Ottaviani S, Bardin T, Richette P. Usefulness of ultrasonography for gout. Joint Bone Spine. 2012 Oct;79(5):441–445.
  13. Stacy GS, Bonham J, Chang A, Thomas S. Soft-tissue tumors of the hand—imaging features. Can Assoc Radiol J. 2020 May;71(2):161–73.
  14. Wittoek R, Jans L, Lambrecht V, et al. Reliability and construct validity of ultrasonography of soft tissue and destructive changes in erosive osteoarthritis of the interphalangeal finger joints: A comparison with MRI. Ann Rheum Dis. 2011 Feb;70(2):278–283.

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