When asked about the clinical implications of her study, Dr. Bokarewa responded by e-mail that, “For general practitioners and for rheumatologists, I would recommend to test the levels of survivin in blood circulation. High levels will indicate patients with severe and joint-destructive disease. High levels of survivin are tightly connected with progression of joint destruction and poor response to antirheumatic treatment. It is a valuable parameter to analyze in parallel with such accredited parameters as rheumatoid factor and antibodies to cyclic citrulinated peptides.”
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She added, “We have preliminary data which would show that survivin (or survivin-related proteins) is a promising therapeutic target in arthritis.”
Dr. Pullen is a medical writer based in the Chicago area.
1. Andersson SE, Svensson MN, Erlandsson MC, Dehlin M, Andersson KM, Bokarewa MI. Activation of Fms-like tyrosine kinase 3 signaling enhances survivin expression in a mouse model of rheumatoid arthritis. PLoS One. 2012;7:e47668.