The ACR Helps Diversify Lupus Research

While African Americans and Hispanics—especially women in these ethnic groups—are disproportionately affected by lupus, they are under-represented in clinical trials in lupus and other chronic diseases.^1,2 With the help of a new federal grant, the ACR took the first step to address this lack of diversity in lupus trials this year.

The ACR’s Collaboration Initiatives (COIN) department and collaborators have launched Materials to Increase Minority Involvement in Clinical Trials (MIMICT), a new program to develop and evaluate communication strategies for clinical trial personnel. MIMICT includes free educational materials to help clinical trial investigators build relationships with each other and with referring physicians in their areas, and, ultimately, to help them effectively communicate with African American or other minority patients with lupus. MIMICT is part of the ACR’s Lupus Initiative.

Awareness Gaps

Barriers to minority participation in lupus clinical trials may exist in part because treating physicians lack awareness about current trials and their protocols, says Sheryl McCalla, senior director, collaborative initiatives, at the ACR. Historical events may also affect some patients’ trust of the medical profession, she adds.

“The lack of diversity in clinical trials reduces opportunities for discovering potential differences in the effects treatments may have in disparate groups of patients. Diverse sampling in trials can tell us how a treatment may affect people in different patient populations,” Ms. McCalla says. “So there is a great benefit to society—to see how treatments work in different patients—and also to improve the treatment of patients in general. But there are many challenges in getting people to enroll in clinical trials.”

Clinical trial results often do not reflect the actual patient population with this disease, so diversifying participation can help refine the quality of study results, says Ms. McCalla.

The ACR will expand MIMICT with the help of a new, two-year grant from the U.S. Department of Health and Human Services Office of Minority Health. This project will be led by ACR members, Saira Z. Sheikh, MD, assistant professor, rheumatology, allergy & immunology, University of North Carolina at Chapel Hill, and Allen Anandarajah, MD, MS, associate professor, allergy, immunology and rheumatology, University of Rochester Medical Center, Rochester, N.Y. If it succeeds, the model may be adapted to boost minority trial recruitment in other diseases, says Ms. McCalla. Funding for the first year is $500,000, and the second year of funding is expected to be the same, she says.