Video: Every Case Tells a Story| Webinar: ACR/CHEST ILD Guidelines in Practice

An official publication of the ACR and the ARP serving rheumatologists and rheumatology professionals

  • Conditions
    • Axial Spondyloarthritis
    • Gout and Crystalline Arthritis
    • Myositis
    • Osteoarthritis and Bone Disorders
    • Pain Syndromes
    • Pediatric Conditions
    • Psoriatic Arthritis
    • Rheumatoid Arthritis
    • Sjögren’s Disease
    • Systemic Lupus Erythematosus
    • Systemic Sclerosis
    • Vasculitis
    • Other Rheumatic Conditions
  • FocusRheum
    • ANCA-Associated Vasculitis
    • Axial Spondyloarthritis
    • Gout
    • Psoriatic Arthritis
    • Rheumatoid Arthritis
    • Systemic Lupus Erythematosus
  • Guidance
    • Clinical Criteria/Guidelines
    • Ethics
    • Legal Updates
    • Legislation & Advocacy
    • Meeting Reports
      • ACR Convergence
      • Other ACR meetings
      • EULAR/Other
    • Research Rheum
  • Drug Updates
    • Analgesics
    • Biologics/DMARDs
  • Practice Support
    • Billing/Coding
    • EMRs
    • Facility
    • Insurance
    • QA/QI
    • Technology
    • Workforce
  • Opinion
    • Patient Perspective
    • Profiles
    • Rheuminations
      • Video
    • Speak Out Rheum
  • Career
    • ACR ExamRheum
    • Awards
    • Career Development
  • ACR
    • ACR Home
    • ACR Convergence
    • ACR Guidelines
    • Journals
      • ACR Open Rheumatology
      • Arthritis & Rheumatology
      • Arthritis Care & Research
    • From the College
    • Events/CME
    • President’s Perspective
  • Search

Ustekinumab Improves Spondylitis in Patients with Psoriatic Arthritis

Will Boggs, MD  |  May 3, 2016

NEW YORK (Reuters Health)—The anti-interleukin (IL)-12/IL-23 monoclonal antibody ustekinumab improves signs and symptoms of spondylitis in patients with psoriatic arthritis, according to a post-hoc analysis of data from the PSUMMIT-1 and PSUMMIT-2 trials.

“This treatment did seem to have a benefit on axial symptoms,” Dr. Arthur Kavanaugh from the University of California San Diego, La Jolla, Calif., tells Reuters Health by email. “Right now, it is approved for psoriatic arthritis treatment; it has a particularly strong effect on skin psoriasis, so is worth considering in such patients, although the biologic agents patients typically go to first are the [tumor necrosis factor] TNF-inhibitors.”

ad goes here:advert-1
ADVERTISEMENT
SCROLL TO CONTINUE

As many as 30% of patients with psoriasis also have psoriatic arthritis, and 25% to 75% of patients with psoriatic arthritis have inflammatory axial involvement/spondylitis.

Dr. Kavanaugh and colleagues assessed the efficacy and safety of ustekinumab in 256 psoriatic arthritis patients with peripheral arthritis and physician-reported spondylitis who had participated in the two Phase 3 studies that supported the regulatory approval of ustekinumab for psoriatic arthritis.

ad goes here:advert-2
ADVERTISEMENT
SCROLL TO CONTINUE

Significantly more patients treated with ustekinumab (54.8%) than with placebo (32.9%) achieved at least a 20% improvement in the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI20) at Week 24, according to the April 20 Annals of the Rheumatic Diseases online report.

Ustekinumab-treated patients were also more likely than placebo-treated patients to achieve BASDAI50 (29.3% vs. 11.4%, respectively) and BASDAI70 (15.3% vs. 0%, respectively).

At Weeks 12 and 24, ustekinumab-treated patients experienced significant improvements in Ankylosing Spondylitis Disease Activity Score incorporating C-reactive protein (ASDAS-CRP), as well with mean improvements approaching 30% at Week 24 vs. <5% with placebo.

As expected, ustekinumab-treated patients were more likely than placebo-treated patients to show significant improvements and other measures of psoriatic arthritis. Ustekinumab also brought greater improvements in physical function, quality of life and radiographic progression, compared with placebo.

Adverse event rates were comparable between the treatment arms, including all adverse events, serious adverse events, discontinuations due to adverse events and infections.

“[Although] interesting, these data need to be replicated formally,” Dr. Kavanaugh concludes.

Janssen Research and Development funded studies for data in this analysis and employed four coauthors. Three other coauthors reported disclosures.

Share: 

Filed under:Axial SpondyloarthritisBiologics/DMARDsConditionsDrug UpdatesPsoriatic Arthritis Tagged with:axial spondyloarthritis (SpA)PsoriasisPsoriatic Arthritisustekinumab

Related Articles

    FDA Approves Ustekinumab for Children with PsA

    November 7, 2022

    After examining study data from pediatric patients with both psoriasis and psoriatic arthritis (PsA), the FDA approved ustekinumab as a treatment for patients aged 6–17 years old with PsA.

    Case Report: A Psoriatic Arthritis Patient with Dactylitis & Enthesitis

    September 20, 2018

    A 36-year-old woman presented at the Johns Hopkins Arthritis Center for a second opinion regarding a diagnosis of psoriatic arthritis (PsA). One year prior to our evaluation, she had developed pain and stiffness in her hands, feet, knees, ankles, elbows and shoulders. She had mild plaque psoriasis of the scalp and base of the neck,…

    Psoriatic Arthritis: Advances in Therapeutics, Imaging & More Presented at ACR Convergence 2022

    December 1, 2022

    PHILADELPHIA—Selecting my top 10 picks for abstracts in psoriatic arthritis (PsA) at the ACR Convergence 2022 meeting was not easy because there was a great deal to review and learn from the 139 abstracts submitted to the meeting. I focused first and foremost on advances in therapeutics that encompassed both new and approved therapeutics, novel…

    kenary820 / shutterstock.com

    Rheumatology Drugs at a Glance, Part 1: Psoriatic Arthritis

    April 15, 2019

    Over the past few years, biosimilars and other new drugs have been introduced to treat rheumatic illnesses. Some of the conditions we treat have numerous drug options, others have few or only off-label options. This series, Rheumatology Drugs at a Glance, provides streamlined information on the administration of biologic, biosimilar and other medications used to…

  • About Us
  • Meet the Editors
  • Issue Archives
  • Contribute
  • Advertise
  • Contact Us
  • Copyright © 2025 by John Wiley & Sons, Inc. All rights reserved, including rights for text and data mining and training of artificial technologies or similar technologies. ISSN 1931-3268 (print). ISSN 1931-3209 (online).
  • DEI Statement
  • Privacy Policy
  • Terms of Use
  • Cookie Preferences