Year in Review: Expert Covers 2017’s Key Clinical Findings

“Gastric bypass associates with a reduced risk of PsO and PsA, possibly providing insights into metabolic correlates associated with PsO and PsA,” Dr. Solomon said. The results are only hypothesis generating, he cautioned.

Biologic DMARDs & Cancer Risk

Dr. Solomon said an observational study in JAMA Internal Medicine was important because “this is a typical patient question [for which] we need better data.”⁸

The study combined Swedish RA cohorts with cancer registries. Researchers found no increased cancer risk for TNF inhibitors across patients grouped by duration of use, even past four years of use. Researchers did find a “suggestion” of an increased risk with abatacept compared with TNF inhibitors for squamous cell skin cancers and melanoma, findings Dr. Solomon said “need further analysis.”

But overall, he said, “These results should increase confidence that TNF inhibitors are not associated with malignancy.”

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