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Gout and Crystalline Arthritis

Updates on ACR Gout Guideline, FDA’s Febuxostat Warning & Pegloticase Therapy

Jason Liebowitz, MD, FACR  |  November 19, 2021

A presentation at ACR Convergence 2021 discussed the 2020 ACR Guideline for the Management of Gout, the latest information on the risk of cardiovascular death associated with febuxostat and the use of pegloticase for patients with gout.

Gout Research at a Glance: ‘My picks for the top research in gout presented at ACR Convergence 2021’

Lisa Stamp, MBChB, PhD  |  November 10, 2021

Dr. Lisa Stamp helps filter the noise to get to the key insights from the research abstracts on gout presented at ACR Convergence 2021.

Colchicine: An Ancient Drug with Modern Uses

Ibrahem Salloum, MD, & Deepan S. Dalal, MD, MPH  |  August 11, 2021

Discovered more than 3,000 years ago, colchicine is one of the oldest drugs still in use today. Like most old remedies, colchicine is a chemical substance found in many plants, most notably in colchicum autumnale, known as wild saffron or autumn crocus. It was mentioned in the oldest Egyptian medical text, Ebers Papyrus (circa 1550…

Case Report: Does a Young Woman with Gitelman Syndrome Have Gout?

Rebecca Lindsey Weiner, DO, & Ann K. Rosenthal, MD, FACP  |  June 14, 2021

Gout is the most common type of inflammatory arthritis in adults, and it typically occurs in men over the age of 50. When gout presents in younger patients or in women, this should warrant consideration of secondary causes. We describe an unusual genetic cause of tophaceous gout in a young, premenopausal woman. Case Report In…

Pegloticase Safe & Effective for Patients with Gout on Dialysis

Michele B. Kaufman, PharmD, BCGP  |  May 19, 2021

Pegloticase is safe and effective to treat patients with refractory gout who are undergoing dialysis, according to recently presented research.

Reducing Immunogenicity of Pegloticase (RECIPE) with Concomitant Use of Mycophenolate Mofetil in Patients with Refractory Gout—a Phase II Double Blind Randomized Controlled Trial

Puja Khanna, Dinesh Khanna, Gary Cutter, Jeffrey Foster, Joshua Melnick, Sara Jaafar, Stephanie Biggers, AKM Rahman, Hui-Chen Kuo, Michelle Feese and Kenneth Saag  |  December 10, 2020

Short-term concomitant use of MMF with pegloticase was generally well tolerated in this proof-of-concept study. It was associated with a statistically significant and clinically meaningful impact on the proportion of subjects achieving and maintaining a sUA ≤6 mg/dL at 24 weeks. See the abstract with bonus video discussing the validation of proposed remission and completion criteria for the treatment of gout.

Dr. Ethan Craig Picks His Favorite Gout Abstracts from ACR Convergence 2020

Keri Losavio  |  November 19, 2020

In light of the release of the ACR’s new gout guideline, it’s not surprising that 50 abstracts of studies on various aspects of gout were accepted at ACR Convergence 2020. Here, we highlight just a few:

Optimize Gout Management with the Latest Evidence-Based Guidance

Mary Beth Nierengarten  |  November 17, 2020

ACR Convergence 2020—In May 2020, the ACR published its updated guideline for the management of gout.1 It followed on the heels of a 2017 gout guideline published by the American College of Physicians.2 Although the guidelines provide similar recommendations on the treatment of acute gout, they differ importantly in the use of uric acid-lowering therapy…

FAST Results for Febuxostat Safety in Patients with Gout

Keri Losavio  |  November 12, 2020

ACR CONVERGENCE 2020—The results of a post-authorization study comparing the cardiovascular safety of febuxostat vs. allopurinol were presented in a late-breaking abstract session at the ACR’s fully virtual annual meeting on Monday, Nov. 9. Cardiologist Thomas MacDonald, MD, FRCP, MBChB, clinical professor (teaching and research) of molecular and clinical medicine, University of Dundee School of…

Lessons from Master Clinicians: An Interview with Dr. Alan Baer

Jason Liebowitz, MD, FACR  |  November 12, 2020

Rheumatologists who are outstanding clinicians and provide consistent, exceptional care to patients are in the spotlight in our Lessons from a Master Clinician series. Here, we present insights from a clinician who has achieved distinction in the field of rheumatology, serving as a role model for colleagues and trainees. Alan Baer, MD, is currently a…

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