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Osteoarthritis and Bone Disorders

Semaglutatide for Patients with Knee Osteoarthritis?

Bryn Nelson, PhD  |  April 8, 2025

Based on decades of data from dietary and other lifestyle interventions, doctors have long known that significant weight loss can be an effective treatment for people who are overweight and have knee osteoarthritis (OA). One meta-analysis showed that OA pain, function and stiffness scores improved by 2% for every 1% in lost weight.1 But the…

New Study Probes Risks Related to Acetaminophen Use

Vanessa Caceres  |  April 7, 2025

A new study questions whether acetaminophen is a risk-free pain reliever for patients aged 65 and older, including those with osteoarthritis (OA). Although acetaminophen is often touted as an alternative to non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, a population-based cohort study found it carried an increased risk of peptic ulcers, bleeding and other side…

Can MRI Predict Osteoarthritis’ Progression?

Arthritis & Rheumatology  |  January 22, 2025

In individuals without radiographic knee osteoarthritis (OA), Chang et al. investigated whether magnetic resonance imaging (MRI) defined knee OA at baseline was associated with incident radiographic and symptomatic disease during up to 11 years of follow-up. The researchers found the two current MRI definitions of knee OA may not adequately predict the development of radiographic and symptomatic disease.

Sunrise, Sunset: A Look Back on the Year in Rheumatology

Jason Liebowitz, MD, FACR  |  December 4, 2024

At the ACR Convergence 2024 Year in Review lecture, experts discussed advancements in disease understanding and treatments, as well as in basic science.

Case Report: Voriconazole-Induced Periostitis

Amanda Moyer, MD, & Tamiko Katsumoto, MD  |  October 8, 2024

In this case report, a patient with voriconazole-induced periostitis exhibits classic symptoms & elevated ALP levels, which quickly resolve following the discontinuation of voriconazole.

Fracture & an Aging World

Jason Liebowitz, MD, FACR  |  September 24, 2024

Insights into osteoporosis treatments as societies around the world age.

LEVI-04 Promising for Relieving Knee OA Pain

Michele B. Kaufman, PharmD, BCGP  |  September 16, 2024

In a study, all doses of LEVI-04 demonstrated significant pain relief for patients with knee osteoarthritis compared with placebo.

Case Report: Hip Pain in End-Stage Renal Disease

Ilana P. Goldberg, MD, & Samuel Faught, MD  |  September 8, 2024

Renal osteodystrophy is associated with chronic kidney disease (CKD) and its associated metabolic derangements, most commonly CKD stages 3–5. It is often subclassified into four histological subtypes, with definite distinctions unable to be made clinically. These four subtypes, which may only be differentiated by bone biopsy, include: osteitis fibrosa cystica, mixed uremic osteodystrophy, osteomalacia and…

Flipbooks: Patient and Family Education Tools

Aryan Gopinath & Srilatha Kothandaraman, MD  |  June 25, 2024

A school science project demonstrates that flipbooks can be a useful educational tool for patients and their families to learn about rheumatic conditions and their treatment.

Methotrexate Shows Promise for Hand Arthritis

Deborah Levenson  |  June 10, 2024

Methotrexate—an affordable, established drug for rheumatoid arthritis—may also be helpful for patients suffering from osteoarthritis (OA) of the hand, a recent study reports.1 Treatment of hand OA and inflammation with 20 mg of methotrexate for six months had a moderate, but potentially clinically meaningful, effect on reducing pain and stiffness in patients with symptomatic hand…

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