In a Phase 3 study, ixekizumab proved safe and effective to treat adults with ankylosing spondylitis (AS)…
Younger Patients Getting Knees & Hips Replaced
NEW YORK (Reuters Health)—Patients undergoing total joint replacement are younger now than they were in 2000, new research indicates. The average patient undergoing a total hip replacement (THR) in 2014 was 64.9 years, while the average patient in 2000 was 66.3 years. Similarly, the average patient undergoing a total knee replacement (TKR) was 65.9 in…
Study Finds Newer Gout Drug Poses Risk to Heart Patients
(Reuters Health)—Gout sufferers with major pre-existing heart disease face a higher risk of death if they are treated with the drug febuxostat, a large long-term study has concluded. The risk of death from cardiovascular disease was 34% higher with febuxostat than with allopurinol. When researchers considered deaths from any cause, the risk was 22% higher…
Periodontitis May Provide Insight into RA
Researchers explored the role of carbamylated protein (CarP) and neutrophil extracellular traps (NETs) in periodontitis and rheumatoid arthritis (RA). The results showed significantly higher levels of CarP and NETs in patients with both RA and periodontitis than in healthy controls. The data suggest that RA and periodontitis may share an underlying pathogenic mechanism…
Opioids No Better Than NSAIDs for Chronic Back or Arthritis Pain
(Reuters Health)—Acetaminophen, ibuprofen and other nonsteroidal anti-inflammatory drugs (NSAIDs) are better than opioids at easing the intensity of chronic pain in the back, knees or hips, a U.S. experiment suggests. And opioids are no better than these other drugs at reducing how much pain interferes with daily activities, such as walking, working, sleeping or enjoying…
Inflammation in OA: Signs & Treatment Opportunities
The demonstrated connection between persistent effusion-synovitis and cartilage damage in certain osteoarthritis (OA) patients has implications for targeted treatment that updates previous OA treatment parameters…
Lyme Disease Spreads Through Ontario
New research highlights the current geographic areas of Ontario, Canada, associated with Lyme disease and the presence of Ixodes scapularis. The study found the ticks are expanding their range at a rate of 46–55 km/year, with several sites showing the presence of Borrelia burgdorferi, which causes Lyme disease. These findings may help target public health interventions in the areas at greatest risk…
Healthy Diet Linked to Lower Hip Fracture Risk in U.S. Women
(Reuters Health)—Eating an overall healthy diet is tied to a lower risk of hip fracture among women over age 50, a U.S. study suggests. Researchers analyzed decades’ worth of dietary and health data for more than 100,000 U.S. men and women. They found that women who scored highest on the American Healthy Eating Index-2010 (AHEI)…
Synovial Analysis Identifies Distinct Rheumatoid Arthritis Subtypes
NEW YORK (Reuters Health)—Synovial gene expression and histology can be used to divide rheumatoid arthritis (RA) into high, low, and mixed inflammatory subtypes, according to results from the Accelerating Medicine Partnership: RA/SLE Network. “The actionable implication of these findings is that it may be worth considering synovial biopsies in patients who are not responding to…
TNF Inhibitors May Not Be Linked to Cancer Risk in Kids
NEW YORK (Reuters Health)—Using tumor necrosis factor (TNF) inhibitors in children is not significantly associated with cancer risk, according to a new study. “TNF inhibitors are remarkably effective for the treatment of many autoimmune conditions, but physicians worry that they cause cancer,” Dr. Timothy Beukelman from the University of Alabama in Birmingham told Reuters Health…
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