In clinical trials, secukinumab proved safe and effective as a long-term treatment for both palmoplantar and nail psoriasis…
What’s Driving the Pain? Alternative Approaches to Pain Management
Patients can experience many different types of pain, and some patients with chronic pain may believe that only opioids will help them. According to Kelly Weselman, MD, the best way to begin managing pain is to determine its root cause and communicate with the patient about the best approach(es) for decreasing their specific pain…
Stem Cell Transplantation Benefits Patients with Scleroderma
A recently published study gives new insight into an innovative approach to treating patients with severe scleroderma and internal organ involvement. During the six-year study, researchers demonstrated the durability of the beneficial effects of stem cell transplantation in this patient population. Their data also suggest the treatment has the potential to renormalize the autoreactive immune system…
Blacks in U.S. Lose Quality of Life Due to Fewer Knee Replacements
(Reuters Health)—Black people with knee osteoarthritis may have a worse quality of life than white patients in part because they’re less likely to be offered knee replacement surgery or to get the procedure when it’s recommended, a U.S. study suggests. Knee replacement surgery has the potential to greatly relieve suffering from severe joint pain that…
Baricitinib Also Appears Effective in Biologic-Refractory RA
NEW YORK (Reuters Health)—The selective Janus kinase 1 and 2 inhibitor baricitinib appears also to help patients whose rheumatoid arthritis (RA) has not responded adequately to biologic disease-modifying antirheumatic drugs, according to results from the RA-BEACON randomized trial. The previously published overall results from RA-BEACON showed that baricitinib-treated patients had significantly better functional and clinical…
Gene Signatures in IgG4-Related Disease
Research suggests prednisone treatment can selectively modulate the signatures of regulatory T (Treg) cells, eosinophils and neutrophils in patients with IgG4-related disease. The results show IgG4-related disease may result from an imbalance of immune and inflammatory cells…
Chronic Pain Research Probes Neurologic Pain Pathways, Biomarkers
With the aid of increasingly sophisticated neuroimaging technology, research into how the brain activates and changes in patients with chronic pain is delivering fascinating information that will hopefully pave the way to tailored, individual treatment of chronic pain. Over the past several years, data from neuroimaging studies have provided a new understanding of what occurs…
Ankylosing Spondylitis: A Patient’s Perspective
When Marc McClintock first began experiencing back pain, he chalked it up to the rigors of his racing career. For more than 36 years, Mr. McClintock has built and raced stock cars, high-powered race vehicles that compete on short oval or circular dirt or paved tracks. “I live in a commercial building, with my residence on…
3 Experts Discuss Bone Health
SAN DIEGO—At the 2017 ACR/ARHP Annual Meeting Nov. 3–8, experts discussed improving bone health in the U.S., gave tips on bone health disorders in pediatrics and reviewed new translational science findings for joint conservation in early osteonecrosis. E. Michael Lewiecki, MD, director of the New Mexico Clinical Research & Osteoporosis Center in Albuquerque, N.M., called…
DADA2 Research Reveals Mechanisms & Possible Gene Therapy
SAN DIEGO—An increasing number of patients is being identified with deficiency of adenosine deaminase type 2 (DADA2); fortunately, researchers and clinicians continue to better understand the genetic disease as well, experts said in a session at the 2017 ACR/ARHP Annual Meeting Nov. 3–8. The childhood-onset disease involves loss-of-function mutations to the CECR1 gene (i.e., cat…
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