(Reuters Health)—Obese people who have weight loss surgeries, such as gastric bypass, are much less likely than those who don’t have surgery to develop gout, a painful type of arthritis, according to a Swedish study. People who chose to get weight loss surgery are also less than half as likely to develop hyperuricemia, too much…

Treating the Athlete: New Thoughts on How to Prevent & Treat Arthritis in Athletes & Raise Their Awareness
All athletes—amateur and professional—should understand their risks for developing injury-related arthritis. Rheumatologists and other physicians at the Hospital for Special Surgery in New York take a rapid approach to treating athletes, often considering intense physical therapy, innovative treatments and surgery much sooner than for the average patient—all to keep joints healthy and enable athletes to play for as long as possible…
Brain Connectivity Predicts Placebo Response in Chronic Pain Patients
NEW YORK (Reuters Health)—Brain connectivity differences predict placebo responses in patients with chronic knee osteoarthritis, researchers report. Positive medical responses to placebo treatments are common, but the underlying central nervous system mechanisms remain unclear. Dr. Marwan N. Baliki and colleagues from the Feinberg School of Medicine at Northwestern University in Chicago used resting-state functional MRI…
Statins & the Risk of RA
Statins have anti-inflammatory/immunomodulatory effects that may be useful in preventing rheumatoid arthritis (RA), but previous observational studies about the risk of RA with statin use yielded conflicting results. In this large population-based study, high-intensity statin treatment was associated with a 23% reduced risk of RA when compared with low-intensity statin treatment. This is the largest study on the association of statins with RA risk to date, and the first to assess the effect of relative statin strength…

SSRIs Act Centrally to Cause Bone Loss
In a recent study, investigators examined the effects of both the short- and long-term use of selective serotonin-reuptake inhibitors (SSRIs) on the development and loss of bone. The study results describe the mechanisms by which SSRIs, specifically fluoxetine, affect osteoclasts short term to increase bone mass, but also how the treatment may cause bone loss at six weeks in mice…
Can Nasal Tissue Be Used to Repair a Damaged Knee Joint?
(Reuters Health)—Doctors might one day be able to harvest cells from patients’ noses to produce cartilage that can be transplanted into damaged knee joints, a small experiment suggests. Because the experiment only included 10 adults who were followed for just two years, it’s impossible to say for sure whether this procedure would be safe or…
New Treatment Guidelines to Be Presented at the 2016 ACR/ARHP Annual Meeting
Two sets of guidelines—one on managing anti-rheumatic drugs perioperatively for patients undergoing total hip and knee replacements, and another that updates glucocorticoid-induced osteoporosis prevention and treatment strategies—will be featured in sessions at the 2016 ACR/ARHP Annual Meeting this month. The Sessions Sunday, Nov. 13, 2:30–3:30 p.m.: Glucocorticoid-Induced Osteoporosis Prevention and Treatment: A New ACR Clinical…

Tocilizumab Designated as Breakthrough Therapy for GCA
To speed the development of tocilizumab to treat giant cell arteritis (GCA), the FDA designated it as a breakthrough therapy earlier this month…

Otulipenia: From Inflammatory Case Studies to Treatment
Otulipenia is a recently discovered autoinflammatory disease caused by germline mutations, which results in dysregulated ubiquitination in patients. In a small-scale study, researchers used exome sequencing and candidate gene screening to identify three different loss-of-function mutations in the OTULIN/FAM105B gene in patients…
Type 1 Diabetes Often Comes with Other Autoimmune Diseases
(Reuters Health)—People with type 1 diabetes often develop other autoimmune disorders, such as thyroid and gastrointestinal diseases, and a recent study yields new information about this link. In the study, 27% of patients with type 1 diabetes had at least one other autoimmune disorder. But the new study also held some surprises about how early…
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