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Other Rheumatic Conditions

Biomarkers Differentiate Crohn’s Disease from Ulcerative Colitis

Marilynn Larkin  |  June 4, 2016

NEW YORK (Reuters Health)—Newly identified biomarkers could aid in the diagnosis of inflammatory bowel disease (IBD) and help guide therapy, Canada-based researchers report. Accurately differentiating between Crohn’s disease (CD) and ulcerative colitis (UC) is important for ensuring early and appropriate treatment. However, the conditions can’t be reliably distinguished based on clinical symptoms, site of disease,…

Innate Immune Response Enters Center Stage for Inflammatory Eye Disease

Lara C. Pullen, PhD  |  April 25, 2016

Researchers suspect the C-type lectin receptor (CLR) mincle may play a role in experimental autoimmune uveoretinitis. A new study linked CLR mincle to Card9-signaling events and IL-1, resulting in inflammation…

2015 ACR/ARHP Annual Meeting: Macrophage Polarization and Its Role in Inflammatory Disease

Susan Bernstein  |  April 14, 2016

SAN FRANCISCO—To unravel how out-of-control inflammation begins in rheumatoid arthritis and other diseases, one target for immunologists is the macrophage. Researchers discussed macrophage activation and other key drivers of inflammation at the 2015 ACR/ARHP Annual Meeting on Nov. 7. How macrophages behave when recognizing damage-associated molecular pathways (DAMPs) tells us more about why some inflammation doesn’t…

2015 ACR/ARHP Annual Meeting: Cellular Triggers in Inflammatory Disease

Susan Bernstein  |  April 14, 2016

SAN FRANCISCO—What factors help determine whether or not inflammation resolves, leading to healing, or becomes chronic, leading to disease and tissue destruction? A number of important cells, including toll-like receptors, mast cells, anti-citrullinated protein antibodies, complement and interferon, all play their own role in this process. By understanding how they act in innate and adaptive…

Scleritis Often Diagnosed by Ophthalmologists, But Rheumatologists Help Determine Systemic Causes

Vanessa Caceres  |  March 15, 2016

Ophthalmologists may be more likely to initially diagnose and treat scleritis, an inflammation of the scleral tissues of the eye. However, rheumatologists need to remain aware of the condition as well: It’s commonly associated with rheumatic disorders, such as rheumatoid arthritis (RA). Scleritis can present in the eye anteriorly or posteriorly. “Anterior scleritis can be…

2015 ACR/ARHP Annual Meeting: Unknowns Persist Around Sarcoidosis Etiology, Pathogenesis, Treatment

Thomas R. Collins  |  March 15, 2016

SAN FRANCISCO—The Kveim-Siltzbach skin test for a diagnosis of sarcoidosis was developed in 1941, then popularized in 1961. Since then, the knowledge base about the disease has not expanded much, said Kristin Highland, MD, who has dual appointments at Cleveland Clinic’s Respiratory Institute and Orthopedics and Rheumatology Institute. “We don’t know a whole lot more…

2015 ACR/ARHP Annual Meeting: Research Lends Insight Into Osteoporosis Treatment, New Auto-Inflammatory Disease, Scleroderma

Thomas R. Collins  |  March 15, 2016

SAN FRANCISCO—Post-menopausal women with osteoporosis, previously treated with oral bisphosphonates, had greater increases in bone density when taking denosumab compared with zoledronic acid over a year’s time, according to a study presented at the 2015 ACR/ARHP Annual Meeting. The findings were discussed in the Discovery 2015 plenary session, which focused on new research. In the…

2015 ACR/ARHP Annual Meeting: Immune Mediators Can Impact Inflammatory Response

Susan Bernstein  |  March 15, 2016

SAN FRANCISCO—Inflammation can be either acute or chronic, and it’s the inflammatory responses that don’t shut down normally, or resolve, that cause tissue damage in rheumatic disease. “Resolution bridges the gap between acute inflammation and adaptive immunity,” said Derek W. Gilroy, PhD, head of the Centre for Clinical Pharmacology and Professor of Immunology at University…

Titanium Dioxide Additives May Boost Intestinal Inflammation

David Douglas  |  March 3, 2016

NEW YORK (Reuters Health)—Murine and other studies suggest that titanium dioxide (TiO2) nanoparticles, widely used as food additives and in drug formulations, may be involved in intestinal inflammation, according to Swiss researchers. As Dr. Gerhard Rogler told Reuters Health by email, “It seems that titanium dioxide nanoparticles are not harmful for a healthy person with…

Insight into Crosstalk Between Bone & Immune Systems

Lara C. Pullen, PhD  |  February 22, 2016

Osteoimmunology is an emerging field that focuses on the interaction between bone and the immune system. CD4+ T cells play an important role in the bone marrow and modulate the differentiation of bone-resorbing osteoclasts. This article reviews the role of CD4+ T cells as an osteoclastogenic population in inflammatory bowel disease…

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