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Search results for: FLARE

Emerging Therapies for Antiphospholipid Syndrome, an Antibody-Mediated Disease

Katie Robinson  |  August 6, 2025

A recent A&R review explores innovative, emerging therapies for the currently incurable, antibody-mediated disease antiphospholipid syndrome.

Filed under:Biologics/DMARDsConditionsDrug UpdatesGuidanceOther Rheumatic ConditionsResearch Rheum Tagged with:AntibodiesanticoagulantAntiphospholipid syndromeautoantibodiesB cellsCAR-T cell therapyHYDROXYCHLOROQUINEImmunology Insightslupus anticoagulantPathogenesisrituximabthrombosiswarfarin

Key Research in Vasculitis Encapsulated

Philip Seo, MD, MHS  |  August 6, 2025

Summaries of selected research abstracts on the assessment & management of systemic vasculitis from ACR Convergence 2024.

Filed under:ACR ConvergenceConditionsMeeting ReportsResearch RheumVasculitis Tagged with:AAV FocusRheumACR Convergence 2024DADA2eosinophilic granulomatosis with polyangiitis (EGPA)Giant Cell ArteritisGlucocorticoidsgranulomatosis with polyangiitisIgG4 related diseaseinebilizumabInterleukinJAK inhibitormepolizumabupadacitinibVasculitis

Editor's Pick

Understanding Immunologic Complications of Measles

Ruth Jessen Hickman, MD  |  August 6, 2025

As measles outbreaks increase domestically & internationally, while vaccination uptake decreases in the U.S., experts discuss treatment recommendations & the immunologic consequences of measles infections in patients with rheumatic diseases.

Filed under:Biologics/DMARDsClinical Criteria/GuidelinesConditionsDrug UpdatesGuidance Tagged with:BiologicsImmunityimmunocompromisedimmunosuppressioninfectious diseaselive vaccineMeaslesMMRoutbreakspublic healthvaccinationvaccine hesitancy

Results for Novel, Glucocorticoid-Sparing Treatment for Patients with PMR

Arthritis & Rheumatology  |  July 31, 2025

A phase 2 study from Spiera et al. found that patients with glucocorticoid-dependent PMR taking the antibody-drug conjugate ABBV-154 had a longer time to flare compared with those taking placebo, supporting further investigation.

Filed under:ConditionsDrug UpdatesOther Rheumatic Conditions Tagged with:ABBV-154glucocorticoid receptor modulatorGlucocorticoidspatient carePMRPolymyalgia Rheumatica

Highlights from the European Congress of Internal Medicine

Vanessa Caceres  |  July 10, 2025

An overview of highlights from the 2025 ECIM meeting, including research on treatment options for systemic sclerosis, the management of PMR & autoimmune testing.

Filed under:ConditionsMeeting ReportsOther Rheumatic ConditionsSystemic Lupus Erythematosus Tagged with:abataceptCAR-T cell therapyEuropean Congress of Internal MedicineGiant Cell ArteritisGlucocorticoidsInterstitial Lung DiseaseMethotrexatenintedanibPolymyalgia Rheumaticarituximabserological testingstem cell transplantationSystemic sclerosis

New Study: Upadacitinib Is Treatment Option for Giant Cell Arteritis

Deborah Levenson  |  July 10, 2025

Results of the international SELECT-GCA study suggest that upadacitinib may be an effective new oral treatment for giant cell arteritis.

Filed under:Biologics/DMARDsConditionsDrug UpdatesResearch RheumVasculitis Tagged with:AAV FocusRheumActemraGCAGiant Cell ArteritisGlucocorticoidsJAK inhibitorsJanus Kinase InhibitorsprednisoneRINVOQtocilizumabupadacitinib

Editor's Pick

Calcium Pyrophosphate Deposition Disease: The Great Mimic

Bryn Nelson, PhD  |  July 9, 2025

CPPD is notoriously difficult to diagnose due to its diverse presentations & uncertain etiology. Recent advances have helped rheumatologists better understand its risk factors, classify, diagnose & treat the condition.

Filed under:ConditionsGout and Crystalline ArthritisOsteoarthritis and Bone DisordersRheumatoid Arthritis Tagged with:arthrocentesiscalcium pyrophosphate deposition diseasechondrocalcinosisColchicineCorticosteroidscrystal arthritisGoutGout Resource CenterinflammationOsteoarthritispseudogoutRheumatoid arthritis

Incarcerated Individuals with Rheumatic Conditions

Katherine Terracina, MD, & Prajakta P. Masurkar, PhD  |  June 8, 2025

In addition to the impediments to consistent, high-quality care suffered by all incarcerated individuals, incarcerated patients with rheumatic disease face challenges specific to the treatment, management & monitoring of rheumatic conditions.

Filed under:EthicsGuidance Tagged with:Chronic disease managementethical considerationsEthics Forumhealth disparitieshealthcare policymedication accesspatient advocacyprison healthcaretelemedicine

Rheuminations: The Metaphors, Mythologies & Rituals of Medicine

Bharat Kumar, MD, MME, FACP, FAAAAI, RhMSUS  |  June 7, 2025

“Doctor, I hate to tell you this but that shelf is definitely not made of wood,” my patient gently chided me as I knocked on a plastic piece of shelving. “I know … but you get the point,” I replied with a small laugh. It’s become a habit of mine over the past few years…

Filed under:OpinionPatient PerspectiveRheuminations Tagged with:physician patient relationship

Trials Find Potential Treatments for SLE, Lupus Nephritis

Michele B. Kaufman, PharmD, BCGP  |  May 31, 2025

In summer 2024, two phase 3 studies were released with promising findings for the treatment of patients with systemic lupus erythematosus (SLE) and those with lupus nephritis. SLE Disease Activity Dapirolizumab pegol is a novel, investigational, Fc-free anti-CD40L agent for people living with moderate to severe SLE.1 The randomized, double-blind, parallel-group PHOENYCS GO trial (N=321)…

Filed under:ConditionsDrug UpdatesSystemic Lupus Erythematosus Tagged with:dapirolizumab pegolLupus nephritis supplementobinutuzumab

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