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FDA Issues Boxed Warning for Hydroxyurea & Neutropenia May Occur after Rituximab Treatments

Michele B. Kaufman, PharmD, BCGP  |  August 26, 2015

The FDA has issued a new boxed warning for Droxia (hydroxyurea). Also, according to a new study, RA patients receiving rituximab should be monitored for late-onset neutropenia…

Filed under:Biologics/DMARDsDrug Updates

Women, Minorities Continue to Be Underrepresented in Medicine

Megan Brooks  |  August 24, 2015

NEW YORK (Reuters Health)—Continued efforts are needed to increase the number of women and minorities in graduate medical education (GME) to ensure a diverse U.S. physician workforce, say the authors of a research letter published today. “Diversifying the physician workforce has been discussed as requisite to addressing health disparities and inequities. Minority physicians continue to…

Filed under:Education & TrainingWorkforce Tagged with:Diversitygraduate medical educationWomen

Depression May Increase Risk of Cardiovascular Disease for RA Patients

Kathryn Doyle  |  August 22, 2015

(Reuters Health)—Mental health problems, like anxiety and depression, may partly explain why people with rheumatoid arthritis have an increased risk of cardiovascular disease, according to a new study. Researchers linked anger, anxiety, depressive symptoms, job stress and low social support to increasing risk of hardening of the arteries, or atherosclerosis, for people with rheumatoid arthritis…

Filed under:ConditionsRheumatoid Arthritis Tagged with:atherosclerosisCardiovascular diseaseDepressionMental HealthRheumatiod arthritisStress

Epratuzumab Results Disappointing, but Adalimumab Promising

Michele B. Kaufman, PharmD, BCGP  |  August 19, 2015

Two Phase 3 trials have shown that epratuzumab did not meet its primary endpoints for treating SLE. Meanwhile, a Phase 3 study has shown adalimumab is effective for treating enthesitis-related arthritis in juveniles…

Filed under:Biologics/DMARDsDrug Updates Tagged with:adalimumabenthesitis-related arthritisepratuzumabJuvenile arthritissystemic lupus erythematosus (SLE)

FDA Warns Makers of Superbug-Prone Scopes over Testing Violations

Reuters Staff  |  August 18, 2015

(Reuters)—Manufacturers of duodenoscopes linked to recent superbug outbreaks at U.S. hospitals skirted a host of testing, manufacturing and reporting requirements, the U.S. Food and Drug Administration said in warning letters to the companies released on Monday. The letters, sent on Aug. 12, cite Olympus Corp Pentax Medical and Fujifilm Holdings Corp with multiple violations found…

Filed under:Uncategorized Tagged with:duodenoscopesFDAInfectionsafety warning

Patients Don’t Realize Smoking Worsens Inflammatory Bowel Disease

Lisa Rapaport  |  August 18, 2015

(Reuters Health)—Doctors know smoking can increase the risk for certain common inflammatory bowel diseases (IBD), but many patients haven’t gotten the message, a new study suggests. Out of 239 patients with two common types of IBD (Crohn’s disease and ulcerative colitis) only half were aware of the smoking risks associated with these conditions. “The take-home…

Filed under:ConditionsOther Rheumatic Conditions Tagged with:Crohn's diseaseinflammatory bowel diseasepatient educationSmokingtobaccoulcerative colitis

RA Diagnosis Uses Lab Tests, Clinical Insight to Rule Out Lyme

Charles Radis, DO  |  August 18, 2015

What struck me first as I walked by the exam room where Lynn P. sat was the swelling in her fingers and wrists. The bloated hands rested unnaturally on her thighs, palms up, fingers slightly flexed. Her strawberry-blond curls were offset by a high-neck, loose-fitting, burgundy sweater. Her pale skin matched her trim slacks. She had…

Filed under:ConditionsRheumatoid Arthritis Tagged with:ClinicalDiagnosislab testLyme Diseasepatient careRheumatoid arthritisrheumatologist

Biosimilar Drugs for RA Studied in Multiple Trials

Michele B. Kaufman, PharmD, BCGP  |  August 17, 2015

Etanercept Biosimilars A number of Phase 3 trials are ongoing for etanercept biosimilars.1 One evaluation identified three trials in rheumatoid arthritis (RA) patients and one in psoriasis patients. The psoriatic arthritis trial evaluated PASI as a primary endpoint and the following secondary endpoints: PASI50, PASI75, PASI90, PASI score, laboratory values, ECG, adverse events (AEs), injection…

Filed under:Biologics/DMARDsConditionsDrug UpdatesRheumatoid Arthritis Tagged with:Biosimilarsclinical trialsDrugsoutcomeRheumatoid arthritisrheumatologySafety

Fellow’s Forum Case Report: Aneurysm in Takayasu’s Arteritis

G.C. Yathish, MD, Taral Parikh, MD, Parikshit Sagdeo, MD, Balakrishnan Canchi, MD, Gurmeet Mangat, MD, & Hemanth Kumar Pandharpurkar, MS  |  August 17, 2015

A healthy 30-year-old Indian male was performing his routine workout in the gym when he developed giddiness and transient blackouts. He thought it was due to exercising excessively. Over the next month, he developed a low-grade fever and started feeling lethargic, to the extent that he was unable to exercise or work. He was admitted…

Filed under:ConditionsVasculitis Tagged with:aneurysmsClinicalpatient carerheumatologistTakayasu’s Arteritis

Catastrophic Antiphospholipid Syndrome with Pulmonary Hemorrhage: A Case Report

Joy-Ann Tabanor, MD, Hyun Bae, MD, Girish Sonpal, MD, & Karlene Williams, MD  |  August 17, 2015

Antiphospholipid syndrome (APS) is an autoimmune condition characterized by hypercoagulability often manifested as recurrent thrombosis or pregnancy complications, with persistently circulating antiphospholipid (aPL) antibodies or lupus anticoagulant. Catastrophic APS (CAPS), also known as Asherson syndrome, occurs in less than 1% of cases of APS and involves occlusive microangiopathy in at least three organ systems.1 Case…

Filed under:ConditionsOther Rheumatic Conditions Tagged with:Antiphospholipid Antibody Syndrome (APS)catastrophic antiphospholipid syndromeClinicalDiagnosishemorrhageHughes Syndromeoutcomepatient carePulmonary

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