CHICAGO—With the approval of the Jak inhibitors (i.e., jakinibs) tofacitinib and ruxolitinib—and others being investigated—rheumatologists need to arm themselves with an understanding of these drugs so they can think critically when evaluating them and deciding how to use them, said John O’Shea, MD, chief of the Molecular Immunology and Inflammation Branch of and scientific director…
Patients with systemic lupus erythematosus (SLE) are characterized by high-titer, highly specific, isotype-switched antibodies against DNA and RNA. Patients have both CD4+ T helper (Th) cell- dependent as well as Th cell-independent autoantibody production. Two mouse models of lupus demonstrate T-cell–independent autoantibody production: the pristane model of lupus, as well as in the MRL/lpr mouse…
New research published in May indicates a possible connection between B cells and the occurrence of systemic lupus erythematosus symptoms.
In 1984, I wrote my first prescription for the antimalarial drug, hydroxychloroquine (Plaquenil), for a 28-year-old woman with SLE. She was considerably overweight, with inflammatory arthritis and a photosensitive rash, and I worried that oral corticosteroids would tip her over into diabetes. I presented the case to my attending, Steven Malawista, MD, at the Yale…
New research compares pathogenic immune response in SLE with immune response that contributes to atherosclerotic plaque
Case report highlights important twist to differential diagnosis of neuropsychiatric lupus
Better understanding of kidney inflammation and fibrosis in LN, along with finding novel disease biomarkers could help rheumatologists gauge patients’ response to therapy
Nurses’ cohort of 38 years provides wealth of patient information, research for rheumatologists
Proper coding for cases of drug-induced gout, systemic lupus erythematosus with lung involvement, inflammatory rheumatoid arthritis, osteoporosis
Coding cases of drug-induced gout, systemic lupus erythematosus with lung involvement, inflammatory rheumatoid arthritis, osteoporosis