Monosodium urate (MSU) crystal formation, deposition and gout flares frequently affect joints that have been damaged or are affected by osteoarthritis. These researchers examined the effects of human cartilage homogenates on MSU crystallization and MSU crystal-induced inflammation…

Year in Review: Rheumatic Disease Research in 2019
ATLANTA—Encouraging data on interleukin (IL) 23/IL-17 pathway drugs in psoriatic arthritis (PsA), JAK inhibitors in rheumatoid arthritis (RA) treatment and new evidence on physical activity and bone health in women were among the highlights of the 2019 ACR/ARP Annual Meeting’s Clinical Year in Review. Susan Manzi, MD, MPH, director of the Lupus Center for Excellence…

2019 EULAR/ACR SLE Classification Criteria Offer Improved Sensitivity & Specificity
The new EULAR/ACR classification criteria for SLE offer improved sensitivity and specificity, as well as more accurately reflect the current tests used to clinically diagnose SLE. A positive ANA test is obligatory…
Cryoglobulins: Quantified & Characterized
This study used up-to-date techniques to perform an exhaustive immunologic description of cryoglobulins with regard to characterization and quantification…

Using RISE Data in Research
The ACR’s RISE registry offers answers on real-world experience to researchers.
What Causes Knee, Hip & Hand Osteoarthritis
Funck-Brentano et al. hypothesized that causal associations for osteoarthritis (OA) may differ by site, and they undertook this study to identify causal risk factors of knee, hip and hand OA.

Lupus Treatments: Into the Future
As the 21st century unfolds, rheumatologists will most likely transition from prescribing lupus patients broad immunosuppressants to more targeted treatment approaches. But to make this happen and advance research, the challenges experienced in lupus clinical trial design must be addressed…

Rheumatology Research Foundation Hosts Annual Investigators Meeting
The Rheumatology Research Foundation hosted the 13th annual Investigators Meeting in Washington, D.C., June 22‒23. The meeting provides Foundation-funded researchers with an opportunity to share updates on their studies, network, exchange ideas and collaborate on future projects to advance treatments and cures for rheumatic diseases. More than 50 rheumatology professionals were in attendance, with presentations…

New ACR Open Rheumatology Journal Delivers Science to Wide Audience
The ACR’s newest journal, ACR Open Rheumatology (ACROR), launched in 2019 with all articles published in full online. The journal publishes high-quality, rigorously peer-reviewed articles on original investigations in rheumatology research, including basic science, clinical science, epidemiology, health outcomes and education, as well as commentaries and reviews. Open access is on the rise. A 2017…
Long-Term Physical Activity Lowers the Risk of RA among Women
A new study adds to the evidence that metabolic factors play an important role in the pathogenesis of rheumatoid arthritis (RA). In this large, prospective cohort study, Liu et al. found that increased physical activity among women was associated with a reduced risk of RA…
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