Patients with systemic lupus erythematosus (SLE) are characterized by high-titer, highly specific, isotype-switched antibodies against DNA and RNA. Patients have both CD4+ T helper (Th) cell- dependent as well as Th cell-independent autoantibody production. Two mouse models of lupus demonstrate T-cell–independent autoantibody production: the pristane model of lupus, as well as in the MRL/lpr mouse…
Naive B Cells Activate & Expand During Lupus Flares
New research published in May indicates a possible connection between B cells and the occurrence of systemic lupus erythematosus symptoms.
Accelerating Medicines Partnership Targets Therapies for Rheumatoid Arthritis, Systemic Lupus Erythematosus
Research collaboration among scientists, pharmaceutical companies, nonprofits promotes precompetitive sharing of data collection, analyses
Lupus Classification Criteria Expanded; Treat-to-Target Approach Gains Support
Rheumatologists at the California Rheumatology Alliance 10th Annual Medical & Scientific Meeting in San Francisco outline disease classification criteria, treat-to-target approach to lupus
Childhood-onset Lupus Brings Distinct Challenges at Each Phase of Life
Differences in disease manifestations, severity, and management require special consideration from rheumatologists who treat children and adolescents with systemic lupus erythematosus
ACR 2013 State-of-the-Art Clinical Symposium: What’s Next in Therapy for Osteoarthritis, Rheumatoid Arthritis, and Lupus?
Experts highlight treatment advances and challenges ahead in OA, RA, and systemic lupus erythematosus (SLE)
California Rheumatology Alliance 2013 Meeting: Rheumatologists Advised to Drop Prednisone Maintenance Therapy in Lupus Patients
A systemic lupus erythematosus (SLE) disease expert emphasizes benefits of hydroxychloroquine, burst of steroid treatments
Nanoparticle Medicine Delivery Shows Promise
Researchers treated mouse model of systemic lupus erythematous with mycophenolic acid delivered via nanoparticle. (posted June 18, 2013)
ACR/ARHP Annual Meeting 2012: New Research Delves Into the Risk of Comorbidities for Patients with Lupus
Studying factors that may lead to life-threatening comorbidities such as lymphoma and thrombosis could give rheumatologists clearer direction on treating patients with SLE
Lupus Survey Finds Gaps in Communication
More than 90% of systemic lupus erythematosus (SLE) patients experience a communication gap with their family and with their care team, according to a recent survey conducted by GfK Roper North America. The survey found that many SLE patients downplay their symptoms to friends, family, and even their doctors.
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