New research evaluated the diagnostic accuracy of 10 clinical tests of hip pathology typically used to diagnosis greater trochanteric pain syndrome (GTPS). However, pain provocation tests, such as the FABER test, proved most useful for ruling out the condition rather than diagnosing it…
By examining the phenotypic plasticity of cartilage and tendon cells, researchers found that oxidative stress and P13K signaling pathways are key modulators of the phenotype of musculoskeletal cells. Using monolayer and three-dimensional cultures, the experiments confirmed that dedifferentiation occurs via reductions in expression of genes for cartilage (Col2a1, Agcn) and tendon (Tnmd, Serpinf1)…
A recent small-scale study showed that patients who received platelet-rich plasma therapy for tendon healing experienced clinically important improvements in pain and disability compared with placebo. Additionally, MRI showed that some participants had improvement in the pathoanatomy of the rotator cuff six months after treatment…
Panush’s perspectives on selections from the literature