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Study Finds NSAIDs Raise Heart Disease Risk in Osteoarthritis Patients

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In a controlled, large-cohort, longi­tudinal study from Canada, Atiquazzaman et al. found that use of non-steroidal anti-inflammatory drugs (NSAIDs) substantially contributes to increased cardiovascular disease risk among people with osteoarthritis (OA).1  This is the first study to evaluate the mediating role that NSAIDs play in the association between OA and cardiovascular disease (CVD), and the… [Read More]

Coronary Microvascular Dysfunction May Predict Heart Disease in Rheumatoid Arthritis

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Cardiovascular disease (CVD) is a leading cause of death in patients with rheumatoid arthritis (RA). Patients with RA have a 1.5 times increased risk for heart attack compared with the general population. Although the treatment of RA has advanced significantly, the ability to prevent cardiovascular events hasn’t followed. A study in Arthritis Care & Research… [Read More]

Dual-Energy CT May Help Detect Gout Patients at Risk for Heart Disease

• By Marilynn Larkin

NEW YORK (Reuters Health)—Dual energy computed tomography (DECT) can differentiate cardiovascular monosodium urate (MSU) deposits from calcium deposits in patients with gout, potentially identifying those at risk of heart disease, researchers say. Sylvia Strobl, MD, of Medical University Innsbruck and colleagues analyzed calcium scores and MSU deposits in 59 patients with gout (mean age: 59;… [Read More]

FDA Rejects Novartis Bid to Repurpose Inflammation Drug for Heart Attacks

• By John Miller

ZURICH (Reuters)—The U.S. Food and Drug Administration (FDA) has rejected Novartis’s bid to repurpose a drug now approved for rare inflammatory diseases to be used in a group of heart attack survivors, according to the Swiss drugmaker. The company received an FDA letter turning down its bid to make canakinumab a targeted therapy for those… [Read More]

Heart of a Champion: The 2018 ACR/ARHP Annual Meeting Kicks Off with Dramatic Keynote

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“You’re probably going to die tonight. You should call your family.” Jonathan Koch, president and CCO of Asylum Entertainment LLC, told his touching and inspiring story of mysterious illness, resilience and recovery in the keynote presentation of the 2018 ACR/ARHP Annual Meeting.... [Read More]

Drug Safety: Fasinumab Evaluated in Clinical Trials, Plus Celecoxib May Not Pose Increased Heart Attack or Stroke Risk

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After an independent review, ongoing clinical trials investigating the safety of fasinumab for treating hip or knee OA will discontinue the use of higher fasinumab doses…... [Read More]

Study Finds Newer Gout Drug Poses Risk to Heart Patients

• By Gene Emery

(Reuters Health)—Gout sufferers with major pre-existing heart disease face a higher risk of death if they are treated with the drug febuxostat, a large long-term study has concluded. The risk of death from cardiovascular disease was 34% higher with febuxostat than with allopurinol. When researchers considered deaths from any cause, the risk was 22% higher… [Read More]

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