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Colchicine: An Ancient Drug with Modern Uses

Ibrahem Salloum, MD, & Deepan S. Dalal, MD, MPH  |  Issue: September 2021  |  August 11, 2021

 

References

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  3. Roddy E, Mallen CD, Doherty M. Gout. BMJ. 2013 Oct 1;347:f5648.
  4. Roubille F, Kritikou E, Busseuil D, Barrere-Lemaire S, Tardif JC. Colchicine: An old wine in a new bottle? Antiinflamm Antiallergy Agents Med Chem. 2013;12(1):14–23.
  5. Leung YY, Yao Hui LL, Kraus VB. Colchicine—Update on mechanisms of action and therapeutic uses. Semin Arthritis Rheum. 2015 Dec;45(3):341–350.
  6. Sardana K, Sinha S, Sachdeva S. Colchicine in dermatology: Rediscovering an old drug with novel uses. Indian Dermatol Online J. 2020 Sep 19;11(5):693–700.
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  15. Lopes MI, Bonjorno LP, Giannini MC, et al. Beneficial effects of colchicine for moderate to severe COVID-19: A randomised, double-blinded, placebo-controlled clinical trial. RMD Open. 2021 Feb;7(1):e001455.
  16. Tardif JC, Bouabdallaoui N, L’Allier PL, et al. Efficacy of colchicine in non-hospitalized patients with COVID-19 [preprint]. medRxiv2021. 2021 Jan 27.
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  18. clinicaltrials.gov. https://clinicaltrials.gov/ct2/results?cond=colchicine+covid&term=&cntry=&state=&city=&dist=.
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  32. Kesselheim AS, Franklin JM, Kim SC, et al. Reductions in use of colchicine after FDA enforcement of market exclusivity in a commercially insured population. J Gen Intern Med. 2015 Nov;30(11):1633–1638.
  33. Gallegos A. Court allows generic colchicine to enter market 2015. Rheumatology News. 2015 Jan 28.
  34. McCormick N, Wallace ZS, Yokose C, et al. Prolonged increases in public-payer spending and prices after unapproved drug initiative approval of colchicine. JAMA Intern Med. 2021 Feb 1;181(2):284–287.
  35. Termination of the Food and Drug Administration’s unapproved drugs initiative; request for information regarding drugs potentially generally recognized as safe and effective. Department of Health and Human Services. hhs.gov. 2020 Nov 20.

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Filed under:ConditionsDrug UpdatesGout and Crystalline Arthritis Tagged with:anti-inflammatoryColchicinedrug treatmentGoutinflammation

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