The Rheumatologist
COVID-19 News
  • Connect with us:
  • Facebook
  • Twitter
  • LinkedIn
  • YouTube
  • Feed
  • Home
  • Conditions
    • Rheumatoid Arthritis
    • SLE (Lupus)
    • Crystal Arthritis
      • Gout Resource Center
    • Spondyloarthritis
    • Osteoarthritis
    • Soft Tissue Pain
    • Scleroderma
    • Vasculitis
    • Systemic Inflammatory Syndromes
    • Guidelines
  • Resource Centers
    • Ankylosing Spondylitis Resource Center
    • Gout Resource Center
    • Rheumatoid Arthritis Resource Center
    • Systemic Lupus Erythematosus Resource Center
  • Drug Updates
    • Biologics & Biosimilars
    • DMARDs & Immunosuppressives
    • Topical Drugs
    • Analgesics
    • Safety
    • Pharma Co. News
  • Professional Topics
    • Ethics
    • Legal
    • Legislation & Advocacy
    • Career Development
      • Certification
      • Education & Training
    • Awards
    • Profiles
    • President’s Perspective
    • Rheuminations
  • Practice Management
    • Billing/Coding
    • Quality Assurance/Improvement
    • Workforce
    • Facility
    • Patient Perspective
    • Electronic Health Records
    • Apps
    • Information Technology
    • From the College
    • Multimedia
      • Audio
      • Video
  • Resources
    • Issue Archives
    • ACR Convergence
      • Systemic Lupus Erythematosus Resource Center
      • Rheumatoid Arthritis Resource Center
      • Gout Resource Center
      • Abstracts
      • Meeting Reports
      • ACR Convergence Home
    • American College of Rheumatology
    • ACR ExamRheum
    • Research Reviews
    • ACR Journals
      • Arthritis & Rheumatology
      • Arthritis Care & Research
      • ACR Open Rheumatology
    • Rheumatology Image Library
    • Treatment Guidelines
    • Rheumatology Research Foundation
    • Events
  • About Us
    • Mission/Vision
    • Meet the Authors
    • Meet the Editors
    • Contribute to The Rheumatologist
    • Subscription
    • Contact
  • Advertise
  • Search
You are here: Home / Articles / Experts Discuss the Latest Precision Medicine Research

Experts Discuss the Latest Precision Medicine Research

February 18, 2018 • By Susan Bernstein

  • Tweet
  • Email
Print-Friendly Version / Save PDF

At his laboratory, Dr. Nigrovic and his colleagues recently developed a new method called SNP-seq (i.e., single nucleotide polymorphism-DNA sequencing) that, with support from the Rheumatology Research Foundation, was employed to screen 27 non-HLA loci in JIA to identify such regulatory variants, finding more than 100 candidate variants.9 They also developed a technique called Flanking Restriction Enhanced Pulldown (FREP) and used it to define two new associations between specific regulatory proteins and two JIA-associated SNPs that modulate expression of the T cell regulatory gene STAT4.10

You Might Also Like
  • Precision Medicine for Lupus Continues to Progress
  • Advances in Precision Immunology Require Precision Controls to Further Research
  • The ACR Pre-Meeting Research Conferences to Explore Immunity, Precision Medicine in Rheumatic Diseases
Explore This Issue
February 2018
Also By This Author
  • Study Finds NSAIDs Raise Heart Disease Risk in Osteoarthritis Patients

“Arthritis transcends the pediatric–adult boundary. We need to unshackle ourselves from the current nomenclature and to unlock the potential of GWAS to reveal new mechanisms involved in this con­tinuum,” he said.

ad goes here:advert-1
ADVERTISEMENT
SCROLL TO CONTINUE

Age of onset nevertheless remains informative, he said. “In most diseases, early onset means genetic loading, suggesting that pediatric-onset disease may be an especially rich area to seek genetically driven disease.” In a new review in Arthritis & Rheumatology, Dr. Nigrovic and his colleagues also explore the continuity of pediatric and adult arthritis from a genetics perspective.11

Genomics Clues Beyond Rheumatology

Rheumatologists can turn to precision medicine research advances in other diseases and outside sources to find methods and concepts that lead to personalized, effective treatment of rheumatic diseases. Cancer researchers pioneered efforts to find genes that contribute to disease risk.

ad goes here:advert-2
ADVERTISEMENT
SCROLL TO CONTINUE

“With few exceptions, it’s never a single penetrative allele or gene. We’re looking for many genes that may contribute to cancer,” said Josh Stuart, PhD, professor in the Biomedical Engineering Department and Baskin Engineering Endowed Chair at the University of California, Santa Cruz. “How we can use an integrative, pathway-level approach to not only classify phenotypes, but select treatments in a patient-specific way?”

Genomics research in a group of patients with the same type of tumor may not show many commonalities, so researchers drill down to the pathway level to find those links. An advanced prostate cancer patient may have various gene mutations, for example. When researchers group him with others who have similar disease, “we look for alterations in the genome, then look for alterations in the transcriptome. Think of the transcriptome as everything that’s different from a matched, normal sample,” said Dr. Stuart. “We’re hoping the genes that interlink the genomic variations to these more transcriptional phenotypic variations are somehow critical to the signaling of the tumor, and if we reverse them, it will somehow have an effect.” The patient’s pathway profile may suggest specific treatment options.

Pages: 1 2 3 4 5 6 7 8 9 10 | Single Page

Filed Under: Meeting Reports, Rheumatoid Arthritis, SLE (Lupus) Tagged With: ACR/ARHP Annual Meeting, Arthritis, big data, Genetic research, genomics, Lupus, Precision Medicine, Rheumatoid arthritisIssue: February 2018

You Might Also Like:
  • Precision Medicine for Lupus Continues to Progress
  • Advances in Precision Immunology Require Precision Controls to Further Research
  • The ACR Pre-Meeting Research Conferences to Explore Immunity, Precision Medicine in Rheumatic Diseases
  • Precision Medicine Latest Initiative in War on Autoimmunity, Rheumatic Illnesses

Simple Tasks

Learn more about the ACR’s public awareness campaign and how you can get involved. Help increase visibility of rheumatic diseases and decrease the number of people left untreated.

Visit the Simple Tasks site »

ACR Convergence

Don’t miss rheumatology’s premier scientific meeting for anyone involved in research or the delivery of rheumatologic care or services.

Visit the ACR Convergence site »

Meeting Abstracts

Browse and search abstracts from the ACR Convergence and ACR/ARP Annual Meetings going back to 2012.

Visit the Abstracts site »

The Rheumatologist newsmagazine reports on issues and trends in the management and treatment of rheumatic diseases. The Rheumatologist reaches 11,500 rheumatologists, internists, orthopedic surgeons, nurse practitioners, physician assistants, nurses, and other healthcare professionals who practice, research, or teach in the field of rheumatology.

About Us / Contact Us / Advertise / Privacy Policy / Terms of Use

  • Connect with us:
  • Facebook
  • Twitter
  • LinkedIn
  • YouTube
  • Feed

Copyright © 2006–2021 American College of Rheumatology. All rights reserved.

ISSN 1931-3268 (print)
ISSN 1931-3209 (online)

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.