The T cell transcriptome analysis did, however, identify biomarkers that may be a source of immune dysfunction in patients with SLE.
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“We expected patients with various clinical signs to show more distinctive expression patterns, as has been shown for rheumatoid arthritis. Our data indicate that the extent of expression alteration in T cells correlates more with the severity of disease rather than which major symptoms were apparent,” write the authors in their discussion.
Lara C. Pullen, PhD, is a medical writer based in the Chicago area.
- Bradley SJ, Suarez-Fueyo A, Moss DR, et al. T cell transcriptomes describe patient subtypes in systemic lupus erythematosus. PLoS One. 2015 Nov 6;10(11):e0141171. doi: 10.1371/journal.pone.0141171. eCollection 2015.