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Grinding Away: An Overview of Progress in the Treatment & Management of Osteoarthritis

Jason Liebowitz, MD, FACR  |  Issue: August 2021  |  June 28, 2021

With regard to medications that have bone-related actions and may provide potential treatment for OA, Dr. Chevalier mentioned two such therapies. The first are molecules that target the Wnt signaling pathway, which appears to be important in regulating and activating cellular and molecular processes during OA development. The second are cathepsin K inhibitors, which seem to have beneficial effects on bone and cartilage in preclinical OA models. Each of these novel therapies holds potential for the treatment of OA, but Dr. Chevalier explained many more studies are needed to truly prove efficacy.


Jason Liebowitz, MD, completed his fellowship in rheumatology at Johns Hopkins University, Baltimore, where he also earned his medical degree. He is currently in practice with Skylands Medical Group, N.J.

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References

  1. Reichenbach S, Felson DT, Hincapié CA, et al. Effect of biomechanical footwear on knee pain in people with knee osteoarthritis: The BIOTOK randomized clinical trial. JAMA. 2020 May 12;323(18):1802–1812.
  2. Allen KD, Woolson S, Hoenig HM, et al. Stepped exercise program for patients with knee osteoarthritis: A randomized controlled trial. Ann Intern Med. 2021 Mar;174(3):298–307.
  3. Li ZH, Gao X, Chung VC, et al. Associations of regular glucosamine use with all-cause and cause-specific mortality: A large prospective cohort study. Ann Rheum Dis. 2020 Jun;79(6):829–836.
  4. Wang Z, Jones G, Winzenberg T, et al. Effectiveness of Curcuma longa extract for the treatment of symptoms and effusion-synovitis of knee osteoarthritis: A randomized trial. Ann Intern Med. 2020 Dec 1;173(11):861–869.
  5. Davis CR, Ruediger CD, Dyer KA, et al. Colchicine is not effective for reducing osteoarthritic hand pain compared to placebo: A randomised, placebo-controlled trial (COLAH). Osteoarthritis Cartilage. 2021 Feb;29(2):208–214.

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Filed under:ConditionsEULAR/OtherMeeting ReportsOsteoarthritis and Bone Disorders Tagged with:dietary supplementEULARhandhand osteoarthritisKnee Osteoarthritis (OA)osteoarthritis (OA)

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