Microbiome Sequencing
In the modern world of commercially available genetic sequencing, Dr. Scher stated it is not a far-fetched idea that, one day, microbiome sequencing will become available to patients and require interpretation by a host of healthcare providers, including those in the field of rheumatology. With the burgeoning understanding of the role microbiota may play in the pathogenesis of ankylosing spondylitis, it will be incumbent upon rheumatologists to learn more about this topic to help guide patients.
As many practicing rheumatologists know already, patients are eager to understand the role diet and the environment may play in inflammatory pathways and the development of autoimmune disease, and the microbiome is a part of this larger picture. Even though it may be many years from now before physicians can give specific recommendations on how to change diet, avoid antimicrobials, repopulate gut flora with probiotics and other interventions, and ultimately select personalized therapy for patients with ankylosing spondylitis and other conditions in the category of spondyloarthritis, it is more than a gut feeling that this area of research will continue to grow more and more important in the years to come.
Jason Liebowitz, MD, completed his fellowship in rheumatology at Johns Hopkins University, Baltimore, where he also earned his MD. He is currently in practice with Arthritis, Rheumatic, & Back Disease Associates, New Jersey.
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