Video: Knock on Wood| Webinar: ACR/CHEST ILD Guidelines in Practice

An official publication of the ACR and the ARP serving rheumatologists and rheumatology professionals

Immune System Targeted for Research into New Rheumatoid Arthritis Treatments

  |  Issue: March 2017  |  

“We have here a very complex understanding of macrophages,” he said. “Everything is being hit at once, so it’s not a clearly an M1/M2 in vivo system. It’s really a complex set of pathways that are all being activated.”

Thomas Collins is a freelance medical writer based in Florida.

ADVERTISEMENT
SCROLL TO CONTINUE

Miss Any of These Important Sessions?

If you missed any of these important sessions, find them on SessionSelect.

References

  1. Mor A, Dustin ML, Philips MR. Small GTPases and LFA-1 reciprocally modulate adhesion and signaling. Immunol Rev. 2007 Aug;218:114–125.
  2. Misharin AV, Cuda CM, Saber R, et al. Nonclassical Ly6C(-) monocytes drive the development of inflammatory arthritis in mice. Cell Rep. 2014 Oct 23;9(2):591–604.
ADVERTISEMENT
SCROLL TO CONTINUE

Related Articles

    RA Treatment Options: Researchers Explore Groundwork for New Therapies

    WASHINGTON, D.C.—Researchers at the 2016 ACR/ARHP Annual Meeting discussed how they are exploring the immune system in search of groundwork for new rheumatoid arthritis (RA) treatments. The new avenues, supported by the Rheumatology Research Foundation, involve T cell adhesion, new understanding of the role of macrophages and insights into the way IgG glycans function. ad…

    2015 ACR/ARHP Annual Meeting: Macrophage Polarization and Its Role in Inflammatory Disease

    SAN FRANCISCO—To unravel how out-of-control inflammation begins in rheumatoid arthritis and other diseases, one target for immunologists is the macrophage. Researchers discussed macrophage activation and other key drivers of inflammation at the 2015 ACR/ARHP Annual Meeting on Nov. 7. How macrophages behave when recognizing damage-associated molecular pathways (DAMPs) tells us more about why some inflammation doesn’t…

    IgG from Patients with Autoimmune Disease Activates Neutrophils

    A recent study examined the effects of immunoglobulin G (IgG) on isolated neutrophils of patients with autoimmune disease. Researchers found different autoimmune diseases have distinct patterns of IgG-mediated integrin activation and neutrophil function, which may explain disease-specific differences in vascular damage and dysfunction…