“We have here a very complex understanding of macrophages,” he said. “Everything is being hit at once, so it’s not a clearly an M1/M2 in vivo system. It’s really a complex set of pathways that are all being activated.”
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Thomas Collins is a freelance medical writer based in Florida.
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- Mor A, Dustin ML, Philips MR. Small GTPases and LFA-1 reciprocally modulate adhesion and signaling. Immunol Rev. 2007 Aug;218:114–125.
- Misharin AV, Cuda CM, Saber R, et al. Nonclassical Ly6C(-) monocytes drive the development of inflammatory arthritis in mice. Cell Rep. 2014 Oct 23;9(2):591–604.