The investigators were not able to identify allopurinol start dose or previous allopurinol exposure as factors in achieving or maintaining target serum urate.
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“Our study highlights the role of co-morbidities in the achievement of target [serum urate level] with allopurinol,” write the authors. “The presence of two or more co-morbidities was independently associated with 20% lower odds of maintaining target [serum urate level of less than] 6 mg/dL compared with no co-morbidities.”
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The authors conclude that a multifaceted approach with several policy initiatives will be necessary to address these factors that appear to influence the effectiveness of allopurinol.
Lara C. Pullen, PhD, is a medical writer based in the Chicago area.
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Reference
- Singh JA, Yang S, Saag KG. Factors influencing the effectiveness of allopurinol in achieving and sustaining target serum urate in the National Veterans Administration gout cohort. J Rheumatol. 2019 Aug 15. pii: jrheum.190522. [Epub ahead of print]