A mouse model of colitis has revealed that a large number of CD4+CD44+CD62L- memory T cells reside in bone marrow. This CD4+ T cell population appears to act as an osteoclastogenic population during IBD. Research is now focused on better characterizing these putative osteoclastogenic T cells. Studies in IBD suggest that they consist of TNF-α producing Th17 cells that are capable only of limited production of interferon ɣ. However, researchers have yet to identify how these cells are maintained in bone marrow.
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Lara C. Pullen, PhD, is a medical writer based in the Chicago area.
- Wakkach A, Rouleau M, Blin-Wakkach C. Osteoimmune interactions in inflammatory bowel disease: Central role of bone marrow Th17 TNFα cells in osteoclastogenesis. Front Immunol. 2015 Dec 18;6:640. doi: 10.3389/fimmu.2015.00640. eCollection 2015.