NEW YORK (Reuters Health)—Geolocation and ethnicity exert a “strong influence” on the phenotype of primary Sjogren’s syndrome, researchers report.
“The influence of ethnicity on the phenotypic expression of systemic autoimmune diseases has been suggested by various studies, especially in systemic lupus erythematosus, which has been reported as being more frequent and having less favorable outcomes in non-white populations,” note Dr. Manuel Ramos-Casals of the University of Barcelona Hospital Clinic in Spain and colleagues.
“With respect to the influence of geographical factors, a potential north-south gradient in the frequency of autoimmune diseases has been suggested. In primary Sjogren’s syndrome, there is no information on the influence of ethnicity or geolocation on the phenotypic expression of the disease,” they write in Annals of the Rheumatic Diseases, online November 29.
To investigate, the team analyzed information from the Big Data Sjogren Project, “an international, multicenter registry designed in 2014 to take a ‘high-definition’ picture of the main features of primary Sjogren’s syndrome at diagnosis by merging international Sjogren’s syndrome databases,” Dr. Ramos-Casals told Reuters Health.