“Notably, the proportion of patients treated with [immunosuppressive drug] induction therapies progressively decreased over time,” the study says.
Among the 478 patients with outcomes available, 49.6% had complete renal remission in P1, compared with 48.4% in P2 and 58.5% in P3. The incidence of chronic kidney disease and end-stage renal disease lowered over time—it was 7.9% and 24.8% respectively, in P1; 8.5% and 9.1% in P2; and 4.5% and 1.3% in P3 (P<0.0001 for all comparisons). In P1, 20 patients died, compared with nine patients in P2 and eight patients in P3.
The chronic kidney disease-free survival rate at 10 and 20 years was 75% and 66% in P1, respectively; 85.5% and 80.2% in P2; and 91.5% in P3. The end-stage renal disease-free survival at 10 and 20 years was 87% and 80% in P1, respectively; 94% and 90% in P2; and 99% in P3.