Data-Intensive Methodology
The evidence review was conducted using the GRADE methodology, which is designed to be transparent and data driven, and is used worldwide for conducting consensus development, said Timothy E. McAlindon, MD, MPH, the literature review team leader and chief of rheumatology at Tufts Medical Center in Boston.
Panelists generated 203 final PICO (Population Intervention Comparator Outcomes) questions and referenced 85 publications by the end of a thorough review process, he said. Different patient populations’ fracture risks were considered, including adults older or younger than 40, women of childbearing potential for whom some osteoporosis treatments might have maternal or fetal risks, adults on very high-dose glucocorticoids, adults who have received organ transplants and children ages 4–17.
According to Dr. McAlindon, intervention comparators included:
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