The Rheumatologist
COVID-19 NewsACR Convergence
  • Connect with us:
  • Facebook
  • Twitter
  • LinkedIn
  • YouTube
  • Feed
  • Home
  • Conditions
    • Rheumatoid Arthritis
    • SLE (Lupus)
    • Crystal Arthritis
      • Gout Resource Center
    • Spondyloarthritis
    • Osteoarthritis
    • Soft Tissue Pain
    • Scleroderma
    • Vasculitis
    • Systemic Inflammatory Syndromes
    • Guidelines
  • Resource Centers
    • Axial Spondyloarthritis Resource Center
    • Gout Resource Center
    • Psoriatic Arthritis Resource Center
    • Rheumatoid Arthritis Resource Center
    • Systemic Lupus Erythematosus Resource Center
  • Drug Updates
    • Biologics & Biosimilars
    • DMARDs & Immunosuppressives
    • Topical Drugs
    • Analgesics
    • Safety
    • Pharma Co. News
  • Professional Topics
    • Ethics
    • Legal
    • Legislation & Advocacy
    • Career Development
      • Certification
      • Education & Training
    • Awards
    • Profiles
    • President’s Perspective
    • Rheuminations
    • Interprofessional Perspective
  • Practice Management
    • Billing/Coding
    • Quality Assurance/Improvement
    • Workforce
    • Facility
    • Patient Perspective
    • Electronic Health Records
    • Apps
    • Information Technology
    • From the College
    • Multimedia
      • Audio
      • Video
  • Resources
    • Issue Archives
    • ACR Convergence
      • Gout Resource Center
      • Axial Spondyloarthritis Resource Center
      • Psoriatic Arthritis
      • Abstracts
      • Meeting Reports
      • ACR Convergence Home
    • American College of Rheumatology
    • ACR ExamRheum
    • Research Reviews
    • ACR Journals
      • Arthritis & Rheumatology
      • Arthritis Care & Research
      • ACR Open Rheumatology
    • Rheumatology Image Library
    • Treatment Guidelines
    • Rheumatology Research Foundation
    • Events
  • About Us
    • Mission/Vision
    • Meet the Authors
    • Meet the Editors
    • Contribute to The Rheumatologist
    • Subscription
    • Contact
  • Advertise
  • Search
You are here: Home / Articles / Nintedanib Slows Lung Deterioration in General Fibrosing Interstitial Lung Disease

Nintedanib Slows Lung Deterioration in General Fibrosing Interstitial Lung Disease

October 2, 2019 • By Reuters Staff

  • Tweet
  • Email
Print-Friendly Version / Save PDF

NEW YORK (Reuters Health)—Nintedanib dramatically slows lung deterioration in patients with progressive fibrosing interstitial lung diseases, according to a new randomized study.1

You Might Also Like
  • Results for Nintedanib in Patients with Systemic Sclerosis-Associated Interstitial Lung Disease
  • Pattern Recognition Key to Fibrosing Lung Disease Diagnosis
  • Cyclophosphamide for Connective Tissue Disease-Associated Interstitial Lung Disease
Explore This Issue
November 2019

Nintedanib has already been shown to be effective against idiopathic pulmonary fibrosis (IPF). The new trial, funded by the manufacturer, Boehringer Ingelheim, and presented t the European Respiratory Society International Congress 2019 in Madrid, was designed to assess its effectiveness against a broad range of fibrosing lung diseases in 663 volunteers.

ad goes here:advert-1
ADVERTISEMENT
SCROLL TO CONTINUE

After a year of treatment, nintedanib patients had an adjusted rate of decline of 80.8 mL in their forced vital capacity (FVC) compared with a decline of 187.8 mL with placebo (P<0.001).

In patients with an unusual interstitial pneumonia (UIP) like fibrotic pattern, the FVC drop was 82.9 mL vs. 211.1 ml with placebo (P<0.001).

ad goes here:advert-2
ADVERTISEMENT
SCROLL TO CONTINUE

The researchers’ “apparent success in this trial suggests a final common pathway to fibrosis,” Hilary Goldberg, MD, of Brigham and Women’s Hospital, Boston, writes in an editorial in the New England Journal of Medicine, online Sept. 29.2

However, diarrhea was nearly three times more common in the nintedanib group, with rates of 66.9% with the drug and 23.0% with placebo.

And abnormalities in liver-function testing were seven times more common with the drug, with rates of 1.8% for placebo and 13.0% for nintedanib, which is sold under the brand name Ofev.

ad goes here:advert-3
ADVERTISEMENT
SCROLL TO CONTINUE

Additionally, the measures of quality of life used by the researchers did not show a meaningful difference between the two groups.

The INBUILD study was done at 153 sites in 15 countries. The research team enrolled patients with a progressive fibrotic disease other than IPF. People being treated with azathioprine, mycophenolate mofetil, cyclosporine, tacrolimus, cyclophosphamide, rituximab or more than 20 mg per day of glucocorticoids were excluded.

Patients who had troublesome side effects could suspend their therapy or get a lower dose of 100 mg twice daily instead of the usual 150 mg dose.

The company analyzed the data.

The researchers separately assessed patients with UIP, because of previous research suggesting that fibrosis might develop faster in that group. Sixty two percent fell into that category.

The rate of death or acute exacerbation of interstitial lung disease at one year was 7.8% with nintedanib and 9.7% with placebo, a non-significant difference.

The overall rates of adverse events and serious adverse events were comparable in the two groups. However, 19.6% in the nintedanib group discontinued their treatment compared with 10.3% who received placebo.

Pages: 1 2 | Single Page

Filed Under: Drug Updates Tagged With: ILD, Interstitial Lung Disease, lung disease, lungs, nintedanibIssue: November 2019

You Might Also Like:
  • Results for Nintedanib in Patients with Systemic Sclerosis-Associated Interstitial Lung Disease
  • Pattern Recognition Key to Fibrosing Lung Disease Diagnosis
  • Cyclophosphamide for Connective Tissue Disease-Associated Interstitial Lung Disease
  • Transbronchial Lung Cryobiopsy a Valid Diagnostic Option in Interstitial Lung Disease

Simple Tasks

Learn more about the ACR’s public awareness campaign and how you can get involved. Help increase visibility of rheumatic diseases and decrease the number of people left untreated.

Visit the Simple Tasks site »

Meeting Abstracts

Browse and search abstracts from the ACR Convergence and ACR/ARP Annual Meetings going back to 2012.

Visit the Abstracts site »

ACR Convergence

Don’t miss rheumatology’s premier scientific meeting for anyone involved in research or the delivery of rheumatologic care or services.

Visit the ACR Convergence site »

The Rheumatologist newsmagazine reports on issues and trends in the management and treatment of rheumatic diseases. The Rheumatologist reaches 11,500 rheumatologists, internists, orthopedic surgeons, nurse practitioners, physician assistants, nurses, and other healthcare professionals who practice, research, or teach in the field of rheumatology.

About Us / Contact Us / Advertise / Privacy Policy / Terms of Use / Cookie Preferences

  • Connect with us:
  • Facebook
  • Twitter
  • LinkedIn
  • YouTube
  • Feed

Copyright © 2006–2023 American College of Rheumatology. All rights reserved.

ISSN 1931-3268 (print)
ISSN 1931-3209 (online)