In a recent study, upadacitinib proved safe and effective to treat rheumatoid arthritis in patients with inadequate responses to conventional synthetic DMARDs…
Safety, Tolerability & Pharmacodynamics of ABT-122 in Patients with RA
The introduction of biologic disease-modifying anti-rheumatic drugs (DMARDs) has greatly expanded the treatment options for managing rheumatoid arthritis (RA). In many patients, biologic DMARDs improve clinical symptoms, improve function and slow disease progression. Biologic DMARDs are recommended as add-on treatment to conventional synthetic DMARDs, such as methotrexate (MTX) in patients who experienced an incomplete response…
Patients Have Different Hospital Outcomes When Regular Doctors See Them
(Reuters Health)—Many outcomes for hospital patients—including how long they stay and their survival odds after they go home—may depend on whether or not they’re cared for by their primary care physician, a U.S. study suggests. Researchers examined data on 560,651 admissions nationwide for patients covered by Medicare, the U.S. health program for the elderly and…
CVS Health to Acquire Aetna for $69 billion
(Reuters)—U.S. drugstore chain operator CVS Health Corp said on Sunday it had agreed to acquire U.S. health insurer Aetna Inc. for $69 billion, seeking to tackle soaring healthcare spending through lower-cost medical services in pharmacies. This year’s largest corporate acquisition will combine one of the nation’s largest pharmacy benefits managers (PBMs) and pharmacy operators with…
Healthcare Prices Hard to Find Online
(Reuters Health)—Consumers who search online for prices of common medical procedures may be disappointed by what they find, a U.S. study suggests. Researchers used the search engines Google and Bing to check the cost of common services like cholesterol tests, hip replacements and magnetic resonance imaging (MRI) scans in 8 cities: New York; Los Angeles;…
Lacrimal & Tear Fluid Yield Clues to Dry Eye Disease
A recent study suggests novel markers of dry eye disease can be found in the lacrimal fluid and tear fluid of patients. Researchers analyzed the proteins in these fluids and found immune response-related proteins are upregulated at the protein level in lacrimal fluid of patients with dry eye disease and may be an important biomarker…
Multimodal Imaging May Uncover Neural Mechanisms in Pediatric Neuropsychiatric Lupus
In clinical practice, many unknowns exist about how SLE affects the brain—particularly in children. To help these young children battling pediatric SLE, Andrea Knight, MD, MSCE, is examining how advanced neuroimaging techniques may uncover potential inflammatory and non-inflammatory mechanisms of neuropsychiatric dysfunction in lupus…
Consumers with High-Deductible Health Plans Could Be Smarter Shoppers
(Reuters Health)—Even when consumers have health plans that require them to pay a high amount out-of-pocket for care, they often don’t talk to doctors about the price of treatments or shop around to get the best deal, a U.S. study suggests. Researchers focused on high-deductible health plans, which typically have lower monthly premiums than other…
Patient Satisfaction Plummets When Doctors Say ‘No’ to Requests
(Reuters Health)—Patients may become less satisfied with their care when doctors refuse their requests for things, such as prescriptions or lab tests, a U.S. study suggests. Researchers examined data on 1,141 patients with a total of 1,319 doctor visits. Overall, about two-thirds of these visits included at least one patient request for the doctor to…
Rheumatology Guidelines often Based on Weak Evidence
NEW YORK (Reuters Health)—Most recent clinical practice guidelines (CPGs) from the American College of Rheumatology (ACR) are based on expert opinion and lack A-level evidence in support of their recommendations, researchers report. “I’d like to highlight not just for providers but also for patients and policymakers that, even though we in the United States are…
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