NEW YORK (Reuters Health)—In what is believed to be the largest study investigating genetic and clinical determinants of osteoporotic fracture risk, only a genetic predisposition to low bone mineral density (BMD) had a potential causal role to play. “Notably, genetic predisposition to lower levels of vitamin D and estimated calcium intake from dairy sources were…
The FDA Denies Approval for Remoxy Extended Release; Plus Knee OA Pain Treatment Moves into Phase 3 Trials
The FDA has not approved extended release Remoxy, a gel capsule formulation of oxycodone, concluding that its potential benefits do not outweigh its risks…
Phase 2 Trial Results Suggest Baricitinib Is Effective for SLE
A recent study found that baricitinib improved symptoms of arthritis and rash in patients with active SLE, while maintaining a safety profile consistent with previous findings…
Maryland Gets an A; Most States Receive a C on ACR’s 1st Rheumatic Disease Report Card
In a first-of-its-kind report card, the ACR shows that many changes are needed for states to improve patient access to affordable and effective rheumatology care…
An Improved State of Mind?
Evidence suggesting common inflammatory pathways in RA and depression is increasing. However, this study found that improved physical health through pharmacologic treatment does not by itself improve mental health. …
AstraZeneca Lupus Drug Fails to Meet Main Goal in Study
(Reuters)—AstraZeneca’s experimental drug anifrolumab failed to meet its main target in a late-stage clinical study treating patients with moderate to severe lupus, the British drugmaker said on Friday. AstraZeneca said the drug did not meet the main goal in the final-stage of one of the two clinical trials under the TULIP program, failing to show…
Insight into Endothelial Dysfunction in Early SLE Patients without Cardiovascular Disease
The early identification of endothelial dysfunction may be useful in clinical practice to prevent SLE patients from developing atherosclerosis and cardiovascular disease. New research evaluated the use of peripheral arterial tonometry in assessing endothelial dysfunction in patients with early SLE and no cardiovascular risk factors or disease. The results: These patients showed a high rate of endothelial dysfunction and vascular stiffness…
Investigators Assess Infection Risk with RA Biologics
Due to a range of factors, determining the precise infection risk posed by new biologic therapies to RA patients is difficult. But progress has been made and health registries may be helpful, said Olivier Lortholary, MD, PhD, during the 2018 EULAR: Annual European Congress of Rheumatology…
Advocate for Prompt Vasculitis Diagnosis & Treatment
Rheumatologists can act as advocates for patients and their families in a way that supports targeting vasculitis early. Here’s how…
Distinct DNA Methylation Patterns Associated with Myalgic Encephalomyelitis
New research explores the genome-wide epigenetic changes associated with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The results suggest distinct patterns in DNA methylation may become a useful diagnostic marker…
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