Dr. Perlman said it is now a new age in the understanding of macrophages in RA and that the classic in vitro model of M1 and M2 phenotypes of macrophages, with distinct roles and origins, doesn’t hold for an in vivo understanding of what’s going on.
You Might Also Like
Also By This Author
“We have here a very complex understanding of macrophages,” he said. “Everything is being hit at once, so it’s not a clearly an M1/M2 in vivo system. It’s really a complex set of pathways that are all being activated.”
Missed This Important Session?
If you were unable to attend this session during the 2016 ACR/ARHP Annual Meeting, you can catch it now on SessionSelect.
Thomas R. Collins is a freelance writer living in South Florida.
- Mor A, Dustin ML, Philips MR. Small GTPases and LFA-1 reciprocally modulate adhesion and signaling. Immunol Rev. 2007 Aug;218:114–125.
- Misharin AV, Cuda CM, Saber R, et al. Nonclassical Ly6C(-) monocytes drive the development of inflammatory arthritis in mice. Cell Rep. 2014 Oct 23;9(2):591–604.