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You are here: Home / Articles / RA Treatment Options: Researchers Explore Groundwork for New Therapies

RA Treatment Options: Researchers Explore Groundwork for New Therapies

February 7, 2017 • By Thomas R. Collins

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Dr. Perlman said it is now a new age in the understanding of macrophages in RA and that the classic in vitro model of M1 and M2 phenotypes of macrophages, with distinct roles and origins, doesn’t hold for an in vivo understanding of what’s going on.

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“We have here a very complex understanding of macrophages,” he said. “Everything is being hit at once, so it’s not a clearly an M1/M2 in vivo system. It’s really a complex set of pathways that are all being activated.”

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Thomas R. Collins is a freelance writer living in South Florida.

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References

  1. Mor A, Dustin ML, Philips MR. Small GTPases and LFA-1 reciprocally modulate adhesion and signaling. Immunol Rev. 2007 Aug;218:114–125.
  2. Misharin AV, Cuda CM, Saber R, et al. Nonclassical Ly6C(-) monocytes drive the development of inflammatory arthritis in mice. Cell Rep. 2014 Oct 23;9(2):591–604.

Pages: 1 2 3 | Single Page

Filed Under: Conditions, Rheumatoid Arthritis Tagged With: 2016 ACR/ARHP Annual Meeting, ACR/ARHP 2016, ACR/ARHP Annual Meeting, human immunoglobulin G, Rheumatoid Arthritis (RA), Rheumatology Research Foundation, T cell, T cell adhesion

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  • Immune System Targeted for Research into New Rheumatoid Arthritis Treatments
  • 2013 ACR/ARHP Annual Meeting: Researchers Explore Role of Pathogens, Quality of Care in Rheumatoid Arthritis
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  • Researchers Work Toward Early ID & Treatment of Rheumatoid Arthritis

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