Rheumatology Case Report: TINU Syndrome with Concomitant Synovitis

Tubulointerstitial nephritis and uveitis syndrome is a rare oculo-renal inflammatory disease.
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Tubulointerstitial nephritis and uveitis (TINU) syndrome, also known as Dobrin syndrome, is a rare oculo-renal inflammatory disease. It was first described in 1975 by American physician Robert Dobrin, MD.¹ It manifests as acute interstitial nephritis and bilateral uveitis. In addition, patients often experience nonspecific systemic findings, such as fever, weight loss, malaise, myalgia and arthralgia.

TINU syndrome has an excellent prognosis. It has been sporadically documented in case reports in various ophthalmology and nephrology journals. It mostly occurs in adolescents and young females, with a median age of onset of 15 years.² Much of the underlying pathophysiology remains unclear; however, T lymphocytes have been reported to play a significant role in this syndrome.³ Certain associations have been documented, but in most cases, no risk factors are identifiable.⁴

We report a case of TINU syndrome in which the patient initially presented with hand synovitis before the development of oculo-renal disease.

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