The team concluded that Ro60 binds to Alu and primes the RNA-binding innate immune receptors within B cells. This then causes the B cells to make antibodies that target Ro60-Alu RNA, thereby driving disease-causing inflammation.
You Might Also Like
Also By This Author
Lara C. Pullen, PhD, is a medical writer based in the Chicago area.
- Hung T, Pratt GA, Sundararaman B, et al. The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression. Science. 2015 Oct 23;350(6259):455–459. doi: 10.1126/science.aac7442. Epub 2015 Sep 17.