Video: Every Case Tells a Story| Webinar: ACR/CHEST ILD Guidelines in Practice

An official publication of the ACR and the ARP serving rheumatologists and rheumatology professionals

Study Assesses the Role of Genetics & the Gut in Reactive Arthritis

  |  Issue: December 2018  |  

Future Research

Going forward, Dr. Manasson and colleagues emphasize the need for further research to close the gaps that persist in better understanding the interactions between gut microbiota, genetics and susceptibility of postinfectious chronic inflammatory conditions.

Saying these findings contribute to a better understanding of the environmental factors important to the development of various types of chronic arthritis, Dr. Steere emphasizes they do not yet affect how these conditions are diagnosed or treated.

ADVERTISEMENT
SCROLL TO CONTINUE

“The long-range hope is that tests can be developed to help us identify a patient with reactive arthritis and that treatment directed against causative organisms, as well as suppression of immune responses, may be more effective therapy,” he says.

Mary Beth Nierengarten is a freelance medical journalist based in Minneapolis.

ADVERTISEMENT
SCROLL TO CONTINUE

Resources

  1. Manasson J, Shen N, Garcia Ferrer HR, et al. Gut microbiota perturbations in reactive arthritis and postinfectious spondyloarthritis. Arthritis Rheumatol. 2018 Feb;70(2):242–254.

Related Articles
    How HLA-B27 Research Landmarks, Advances Relate to Ankylosing Spondylitis Pathogenesis

    How HLA-B27 Research Landmarks, Advances Relate to Ankylosing Spondylitis Pathogenesis

    The mechanistic link between human leukocyte antigen B27 (HLA-B27) and ankylosing spondylitis (AS) is one of the great enigmas in rheumatology. The introduction of biological therapies that target tumor necrosis factor (TNF) or the interleukin (IL) 23/IL-17A axis has had a major impact on the quality of life for many patients with AS, and one…

    The Microbiome in Pediatric Rheumatic Diseases

    The Microbiome in Pediatric Rheumatic Diseases

    The human intestinal microbiota is home to more than 1,000 bacterial species, containing approximately 3 million genes, many of which code for functions that have the potential to affect human physiology.1 Smaller numbers of organisms are also present in the skin, upper gastrointestinal tract, female reproductive tract and the oro- and nasopharynx. As tools have…

    Conformational Flexibility in HLA-B27 Provides Clues to Development of Ankylosing Spondylitis

    Understanding how human leukocyte antigen (HLA) class I molecule B27 promotes spondyloarthritis has intrigued researchers for four decades. Although the association between the single gene variant HLA-B27—specifically some of its subtypes—with ankylosing spondylitis (AS) is particularly strong, how HLA-B27 directly influences disease development has not yet been clearly explained, although hypotheses continue to be generated….

    Anatomy Insider / shutterstock.com

    Gut Instinct: Ankylosing Spondylitis & the Microbiome

    CHICAGO—At the 2019 ACR State-of-the-Art Clinical Symposium, an annual gathering featuring talks by key opinion leaders on the most salient topics for practicing rheumatologists and healthcare providers, Jose U. Scher, MD, director of the Microbiome Center for Rheumatology and Autoimmunity at NYU Langone Medical Center, New York City, was the featured speaker. In his remarks,…