The Rheumatologist
COVID-19 News
  • Connect with us:
  • Facebook
  • Twitter
  • LinkedIn
  • YouTube
  • Feed
  • Home
  • Conditions
    • Rheumatoid Arthritis
    • SLE (Lupus)
    • Crystal Arthritis
      • Gout Resource Center
    • Spondyloarthritis
    • Osteoarthritis
    • Soft Tissue Pain
    • Scleroderma
    • Vasculitis
    • Systemic Inflammatory Syndromes
    • Guidelines
  • Resource Centers
    • Axial Spondyloarthritis Resource Center
    • Gout Resource Center
    • Psoriatic Arthritis Resource Center
    • Rheumatoid Arthritis Resource Center
    • Systemic Lupus Erythematosus Resource Center
  • Drug Updates
    • Biologics & Biosimilars
    • DMARDs & Immunosuppressives
    • Topical Drugs
    • Analgesics
    • Safety
    • Pharma Co. News
  • Professional Topics
    • Ethics
    • Legal
    • Legislation & Advocacy
    • Career Development
      • Certification
      • Education & Training
    • Awards
    • Profiles
    • President’s Perspective
    • Rheuminations
    • Interprofessional Perspective
  • Practice Management
    • Billing/Coding
    • Quality Assurance/Improvement
    • Workforce
    • Facility
    • Patient Perspective
    • Electronic Health Records
    • Apps
    • Information Technology
    • From the College
    • Multimedia
      • Audio
      • Video
  • Resources
    • Issue Archives
    • ACR Convergence
      • Systemic Lupus Erythematosus Resource Center
      • Rheumatoid Arthritis Resource Center
      • Gout Resource Center
      • Abstracts
      • Meeting Reports
      • ACR Convergence Home
    • American College of Rheumatology
    • ACR ExamRheum
    • Research Reviews
    • ACR Journals
      • Arthritis & Rheumatology
      • Arthritis Care & Research
      • ACR Open Rheumatology
    • Rheumatology Image Library
    • Treatment Guidelines
    • Rheumatology Research Foundation
    • Events
  • About Us
    • Mission/Vision
    • Meet the Authors
    • Meet the Editors
    • Contribute to The Rheumatologist
    • Subscription
    • Contact
  • Advertise
  • Search
You are here: Home / Articles / Study Results for 9 New Psoriatic Arthritis Drugs

Study Results for 9 New Psoriatic Arthritis Drugs

June 21, 2018 • By Thomas R. Collins

  • Tweet
  • Email
Print-Friendly Version / Save PDF
kenary820 / shutterstock.com

kenary820 / shutterstock.com

CHICAGO—As Eric Ruderman, MD, professor of medicine in rheumatology at Northwestern University Feinberg School of Medicine in Chicago, began his talk on psoriatic arthritis treatment at the ACR State-of-the-Art Clinical Symposium in April, he marveled a bit at how much there was to cover. Drugs gaining prominence in the treatment of rheumatoid arthritis and dermatological diseases have begun to carry over into psoriatic arthritis (PsA) research, where many have proved effective.

You Might Also Like
  • Rheumatology Drugs at a Glance, Part 1: Psoriatic Arthritis
  • Apremilast Effective for Psoriatic Arthritis
  • Ustekinumab Improves Spondylitis in Patients with Psoriatic Arthritis
Explore This Issue
June 2018
Also By This Author
  • EULAR & ACR Define Rheumatic & Musculoskeletal Disease for Laymen

“Just a year ago, this talk would have had a lot less involved,” he said.

ad goes here:advert-1
ADVERTISEMENT
SCROLL TO CONTINUE

Biologics are being assessed in PsA at a rapid rate—some with persuasive data, some in small but tantalizing samples, Dr. Ruderman said. As new therapies undergo testing, he said, it’s important to consider how they affect the array of disease manifestations.

“This is not just about joints,” he said. “This is a disease that’s about joints, it’s about skin, it’s about enthesitis, it’s about dactylitis, it’s about nail disease. So many other pieces.”

ad goes here:advert-2
ADVERTISEMENT
SCROLL TO CONTINUE

Dr. Ruderman spoke about several therapies, including apremilast, tofacitinib, abatacept, ustekinumab, ixekizumab, secukinumab, bimekizumab, risankizumab and guselkumab.

Apremilast

This drug—which targets cyclic adenosine monophosphate (cAMP), a regulator of several key immune pathways—works for enthesitis and dactylitis, “[a]nd the drug works quickly. We’re used to that with these targeted small molecules,” Dr. Ruderman said. Effects were seen within two to four weeks.1

He advised clinicians not to misinterpret the drug’s ACR 20% score (ACR20) response rate of 40%. “One thinks, ‘Well, that’s not so good.’… Be careful about assuming that means this drug works less well in the people in whom it works. I think what it really means is, this drug works in fewer people. … The people who respond, some of them actually respond pretty well.”

ad goes here:advert-3
ADVERTISEMENT
SCROLL TO CONTINUE

Importantly, he said, “you’re not seeing the immunosuppressive effects [with apremilast] that raise concern for infections [that] we see with some of the biologic agents we’ve been concerned about.”

More data are needed to sort through what can be confusing options, Dr. Ruderman said. ‘We need good comparative efficacy studies.’

Tofacitinib

This JAK1 and JAK3 inhibitor has been the subject of two PsA trials in the last year, and it was recently approved for PsA. “The tofacitinib response was in the same order of magnitude as we’re used to seeing with adalimumab” among inadequate responders to conventional disease-modifying anti-rheumatic drugs (DMARDs), he said.2

Abatacept

This therapy, which binds CD80 and CD86, produced a “modest” ACR20 response rate of 40%, but it was still superior to placebo and is another option for patients who fail earlier treatments. The response on skin was not impressive, Dr. Ruderman said.

Pages: 1 2 3 | Single Page

Filed Under: Conditions, Drug Updates, Systemic Inflammatory Syndromes Tagged With: abatacept, apremilast, Bimekizumab, guselkumab, ixekizumab, Psoriatic Arthritis, risankizumab, secukinumab, Tofacitinib, ustekinumabIssue: June 2018

You Might Also Like:
  • Rheumatology Drugs at a Glance, Part 1: Psoriatic Arthritis
  • Apremilast Effective for Psoriatic Arthritis
  • Ustekinumab Improves Spondylitis in Patients with Psoriatic Arthritis
  • Long-Term Apremilast Promising for Psoriatic Arthritis

ACR Convergence

Don’t miss rheumatology’s premier scientific meeting for anyone involved in research or the delivery of rheumatologic care or services.

Visit the ACR Convergence site »

Meeting Abstracts

Browse and search abstracts from the ACR Convergence and ACR/ARP Annual Meetings going back to 2012.

Visit the Abstracts site »

American College of Rheumatology

Visit the official website for the American College of Rheumatology.

Visit the ACR »

The Rheumatologist newsmagazine reports on issues and trends in the management and treatment of rheumatic diseases. The Rheumatologist reaches 11,500 rheumatologists, internists, orthopedic surgeons, nurse practitioners, physician assistants, nurses, and other healthcare professionals who practice, research, or teach in the field of rheumatology.

About Us / Contact Us / Advertise / Privacy Policy / Terms of Use

  • Connect with us:
  • Facebook
  • Twitter
  • LinkedIn
  • YouTube
  • Feed

Copyright © 2006–2022 American College of Rheumatology. All rights reserved.

ISSN 1931-3268 (print)
ISSN 1931-3209 (online)