The Rheumatologist
COVID-19 NewsACR Convergence
  • Connect with us:
  • Facebook
  • Twitter
  • LinkedIn
  • YouTube
  • Feed
  • Home
  • Conditions
    • Rheumatoid Arthritis
    • SLE (Lupus)
    • Crystal Arthritis
      • Gout Resource Center
    • Spondyloarthritis
    • Osteoarthritis
    • Soft Tissue Pain
    • Scleroderma
    • Vasculitis
    • Systemic Inflammatory Syndromes
    • Guidelines
  • Resource Centers
    • Axial Spondyloarthritis Resource Center
    • Gout Resource Center
    • Psoriatic Arthritis Resource Center
    • Rheumatoid Arthritis Resource Center
    • Systemic Lupus Erythematosus Resource Center
  • Drug Updates
    • Biologics & Biosimilars
    • DMARDs & Immunosuppressives
    • Topical Drugs
    • Analgesics
    • Safety
    • Pharma Co. News
  • Professional Topics
    • Ethics
    • Legal
    • Legislation & Advocacy
    • Career Development
      • Certification
      • Education & Training
    • Awards
    • Profiles
    • President’s Perspective
    • Rheuminations
    • Interprofessional Perspective
  • Practice Management
    • Billing/Coding
    • Quality Assurance/Improvement
    • Workforce
    • Facility
    • Patient Perspective
    • Electronic Health Records
    • Apps
    • Information Technology
    • From the College
    • Multimedia
      • Audio
      • Video
  • Resources
    • Issue Archives
    • ACR Convergence
      • Gout Resource Center
      • Axial Spondyloarthritis Resource Center
      • Psoriatic Arthritis
      • Abstracts
      • Meeting Reports
      • ACR Convergence Home
    • American College of Rheumatology
    • ACR ExamRheum
    • Research Reviews
    • ACR Journals
      • Arthritis & Rheumatology
      • Arthritis Care & Research
      • ACR Open Rheumatology
    • Rheumatology Image Library
    • Treatment Guidelines
    • Rheumatology Research Foundation
    • Events
  • About Us
    • Mission/Vision
    • Meet the Authors
    • Meet the Editors
    • Contribute to The Rheumatologist
    • Subscription
    • Contact
  • Advertise
  • Search
You are here: Home / Articles / Tanezumab Promising for OA Pain; Plus, Filgotinib Investigated for Psoriatic Arthritis

Tanezumab Promising for OA Pain; Plus, Filgotinib Investigated for Psoriatic Arthritis

August 15, 2018 • By Michele B. Kaufman, PharmD, BCGP

  • Tweet
  • Email
Print-Friendly Version / Save PDF

Subcutaneous Tanezumab Investigated for OA Pain
Tanezumab is an investigational monoclonal antibody that also acts as a non-opioid, nerve growth factor inhibitor. It’s being studied in a subcutaneous formulation to treat knee and hip osteoarthritis (OA) pain.1

You Might Also Like
  • Tanezumab for OA Pain
  • Zilretta Promising for Blood Glucose Levels; Plus Filgotinib Promising for RA
  • Tofacitinib Promising for Psoriatic Arthritis & FDA Issues Alert for Warning for Saxagliptin & Alogliptin Diabetes Treatments
Explore This Issue
September 2018
Also By This Author
  • Tanezumab for OA Pain

In a multicenter, double-blind, placebo-controlled, parallel-group, phase 3 trial, researchers examined tanezumab use in patients with moderate to severe OA pain who had not either receive adequate pain relief from other OA pain treatments or were unable to take other pain medications. Six hundred ninety-eight patients were randomized in a 1:1:1 ratio. Over 16 weeks, they received either two injections of placebo every eight weeks, two injections of 2.5 mg tanezumab every eight weeks or one injection of 2.5 mg tanezumab followed by an injection of 5 mg tanezumab at Week 8. The study included a 24-week safety follow-up.

ad goes here:advert-1
ADVERTISEMENT
SCROLL TO CONTINUE

The Western Ontario and McMaster Universities OA Index Pain subscale, the WOMA Physical Function subscale and the patient’s Global Assessment of OA were used to measure efficacy and safety. Improvement shown by these scales were also the co-primary endpoints.

All tanezumab-treated patients met the co-primary endpoints, demonstrating statistically significant improvement in pain, physical function and patient global assessment. Tanezumab was generally well tolerated, with less than 1.5% of patients discontinuing treatment due to adverse events. No new safety signals were identified.

ad goes here:advert-2
ADVERTISEMENT
SCROLL TO CONTINUE

In June 2017, the U.S. Food and Drug Administration granted tanezumab fast track status to treat OA and chronic low back pain. The agent is also being investigated for cancer pain due to bone metastases.2

Filgotinib in Phase 2 Trials for Psoriatic Arthritis
Filgotinib is a selective JAK1 inhibitor currently undergoing phase 2 clinical trials for psoriatic arthritis and phase 3 trials for ulcerative colitis.3

The randomized, placebo-controlled trial, phase 2 EQUATOR study investigated filgotinib use in 131 adults with moderate to severe psoriatic arthritis. Patients received 200 mg oral filgotinib or placebo once daily. In the study, 85% of patients were TNF inhibitor naive. Its primary endpoint was the improvement in the signs and symptoms of psoriatic arthritis at Week 16 assessed by ACR20.

ad goes here:advert-3
ADVERTISEMENT
SCROLL TO CONTINUE

The results: The ACR20 response was 33% for placebo-treated patients and 80% for filgotinib-treated patients (P<0.001). At Week 12, the ACR50 response was 15% for placebo-treated patients and 48% for filgotinib-treated patients, also statistically significant (P<0.001). Finally, the ACR70 responses were significantly higher at Week 12 for filgotinib-treated patients (23%) than for placebo-treated patients (6%, P<0.01). No new safety signals occurred, and filgotinib was generally well tolerated.

Pages: 1 2 | Single Page

Filed Under: DMARDs & Immunosuppressives, Drug Updates Tagged With: filgotinib, hip, knee, Knee Osteoarthritis (OA), osteoarthritis (OA), Pain, Psoriatic Arthritis, tanezumabIssue: September 2018

You Might Also Like:
  • Tanezumab for OA Pain
  • Zilretta Promising for Blood Glucose Levels; Plus Filgotinib Promising for RA
  • Tofacitinib Promising for Psoriatic Arthritis & FDA Issues Alert for Warning for Saxagliptin & Alogliptin Diabetes Treatments
  • FDA Approves Rituximab Biosimilar; Plus New Safety Data for Filgotinib in RA Patients

Rheumatology Research Foundation

The Foundation is the largest private funding source for rheumatology research and training in the U.S.

Learn more »

ACR Convergence

Don’t miss rheumatology’s premier scientific meeting for anyone involved in research or the delivery of rheumatologic care or services.

Visit the ACR Convergence site »

Patient & Caregiver Resources

Find a rheumatology provider. Learn about your condition and how to live with it. English and Spanish language resources.

View Patient & Caregiver Resources »

The Rheumatologist newsmagazine reports on issues and trends in the management and treatment of rheumatic diseases. The Rheumatologist reaches 11,500 rheumatologists, internists, orthopedic surgeons, nurse practitioners, physician assistants, nurses, and other healthcare professionals who practice, research, or teach in the field of rheumatology.

About Us / Contact Us / Advertise / Privacy Policy / Terms of Use / Cookie Preferences

  • Connect with us:
  • Facebook
  • Twitter
  • LinkedIn
  • YouTube
  • Feed

Copyright © 2006–2023 American College of Rheumatology. All rights reserved.

ISSN 1931-3268 (print)
ISSN 1931-3209 (online)