The aim of the study was to assess the frequency of severe, life-threatening infection and identify the risk factors for development of severe infection, classified as [Common Terminology Criteria for Adverse Events] CTCAE grade ≥3, in patients with AAV who received rituximab. One hundred ninety-two patients with AAV who had been referred for rituximab to two tertiary care specialist centers in Cambridge and Innsbruck, Austria, between 2004 and 2014 were included in the study. Among the 192 patients, 134 were diagnosed with granulomatosis with polyangiitis (GPA), 28 with microscopic polyangiitis (MPA), and 30 with eosinophilic granulomatosis with polyangiitis (EGPA).
“The risk of severe infections was higher than I expected before starting collection of data,” Dr. Kronbichler says.
Follow-up, which began when rituximab therapy was initiated, ended two years later or when a patient died or was lost to follow-up. Mean follow-up was 22.67 months. The researchers found that respiratory tract infections were the leading cause of severe infections. Additionally, they found an association of endobronchial involvement, bronchiectasis and rituximab use for major relapses with severe respiratory tract infections.| ← Previous | | | Next → | Single Page