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Vasculitis

Gary S. Hoffman, MD  |  Issue: June 2009  |  June 1, 2009

It is the hope that new molecular and genetic techniques can take advantage of these vessel differences and bring us closer to a more sophisticated understanding of disease etiology and phenotypes.

Dr. Hoffman is professor and Harold C. Schott Chair of Rheumatic and Immunologic Diseases at the Cleveland Clinic Lerner College of Medicine and founder of the Cleveland Clinic Center for Vasculitis Care and Research.

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References

  1. Topouzis S, Majesky MW. Smooth muscle lineage diversity in chick embryo. Devel Biol. 1996; 178:430-445.
  2. Absi TS, Sundt TM 3rd, Tung WS, et al. Altered patterns of gene expression distinguishing ascending aortic aneurysms from abdominal aortic aneurysms. J Thor Cardiovasc Surg. 2003; 126:344-357.
  3. Red-Horse K, Crawford Y, Shojaei F, Ferrara N. Endothelium-microenvironment interactions in the developing embryo and in the adult. Developmental Cell. 2007;12:181-194.
  4. Chi J-T, Chang HY, Haraldsen G, et al. Endothelial cell diversity revealed by global expression profiling. Proc Ntl Acad Sci USA. 2003;100:10623-10628.
  5. Hallmann R, Horn N, Selg M, Wendler O, Pausch F, Sorokin LM. Expression and function of laminins in embryonic and mature vasculature. Physiology Rev. 2005; 85:979-1000.
  6. Stan RV. Endothelial stomatal and fenestral diaphragms in normal vessels and angiogenesis. J Cell Mol Med. 2007; 11:621-643.
  7. Hoffman GS. Disease patterns in vasculitis —still a mystery. Bull NYU Hosp Jt Dis. 2008;224-227.
  8. Owens GK, Kumar MS, Wamhoff BR. Molecular regulation of vascular smooth muscle differentiation in development and disease. Physiology Rev. 2004; 84:767-801.
  9. Najjar SS, Scuteri A, Lakatta EG. Arterial aging. Is it an immutable cardiovascular risk factor? Hypertension. 2005;46:454-462.
  10. Taddei S, Virdis A, Ghiadoni L, Versari D, Salvetti A. Endothelium, aging, and hypertension. Curr Hyperten Rep. 2006; 8:84-89.
  11. Pryshchep O, Ma-Krupa W, Younge BR, Goronzy JJ, Weyand CM. Vessel-specific toll-like receptor profiles in human medium and large arteries. Circulation. 2008; 118:1276-1284.
  12. Weck K, Dal Canto AJ, Gould JD, et al. Murine γ herpesvirus 68 causes severe large-vessel arteritis in mice lacking interferon-γ responsiveness: a new model for virus-induced vascular disease. Nat Med. 1997;3:1346-1353.
  13. Dal Canto AJ, Swanson PE, O’Guin AK, Speck SH, Virgin HW. IFN-γ action in the media of the great elastic arteries, a novel immunoprivileged site. J Clin Invest. 2001;107:R15-R22.

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