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You are here: Home / Articles / With Genetic Testing Results, More May Be Better

With Genetic Testing Results, More May Be Better

January 26, 2016 • By Kathryn Doyle

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(Reuters Health)—When people undergo genetic testing to find out whether they’re at risk for a specific disease, doctors often wonder how much information to give them. What if the genetic testing results reveal a risk for a disease the patient hadn’t been wondering about?

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Geneticists are “grappling with what to do with all the information that could be disclosed, but wasn’t why the study was ordered in the first place,” Kurt D. Christensen of Brigham and Women’s Hospital in Boston told Reuters Health.

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Though in theory, giving people more risk information than they were expecting might increase anxiety or depression, that didn’t turn out to be the case in a study Christensen recently led.

He and his colleagues studied a group of volunteers who were having tests to see if they’re genetically at risk for Alzheimer’s disease. It turned out these people weren’t more distressed when they received additional results about their risk for coronary artery disease.

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In some cases, those who got extra information were actually less distressed one year later.

“It was the opposite of what we were expecting,” Christensen said in a phone interview.

That might be because patients can do little about their risk for Alzheimer’s disease, but lifestyle changes can help prevent future coronary artery disease, the authors wrote in the Annals of Internal Medicine on Jan. 26.

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These results might help researchers and doctors decide how much information to give patients based on genetic testing results, Christensen said.

The researchers included 257 adults without symptoms, more than half of who had a close relative with Alzheimer’s disease, to be tested for a variant of the apolipoprotein E (APOE) gene, which has a strong association with Alzheimer’s disease risk.

All participants received information about their APOE genotype, cumulative lifetime risk of Alzheimer’s—which ranged from 6% to 73%—and risk up to age 85. Half the group was also told that the same gene variant that increases Alzheimer’s risk may also increase coronary artery disease risk, and that this risk can be reduced by quitting smoking, having a healthy diet, losing weight and treating high cholesterol.

The researchers assessed each subject’s anxiety, depression, distress and health behavior changes like diet and exercise activities at six weeks, six months and 12 months after they received the genetic results.

At the one-year point, anxiety and depression scores were similar in both groups. Among those who were carriers of the high-risk APOE allele, those who were also told about their coronary artery disease risk had lower distress levels and more healthy behavior changes than those who only got Alzheimer’s information.

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Filed Under: Practice Management, Technology Tagged With: Alzheimer's Disease, Genetic research, genetic risk, genetic test, genetics, Testing

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